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Presley_Kayla_dissertation.pdf (5.8 MB)

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Oxygen Sensing Electrospun Nanofibers for Biological Applications

Presley, Kayla Fay
http://rave.ohiolink.edu/etdc/view?acc_num=osu1531616455684609

Abstract Details

2018, Doctor of Philosophy, Ohio State University, Materials Science and Engineering.
Incorporation of luminescent oxygen-sensitive molecules into electrospun polymeric nanofibers can create a sensor with linear Stern-Volmer behavior and a rapid response time. This overcomes several issues associated with traditional polymer film-based sensors. Nevertheless, disadvantages remain that could limit use in biological applications: photobleaching, excitation wavelengths that poorly penetrate tissue and difficulties associated with delivery. This work attempts to address each of these issues. Systematic studies on long-term photobleaching have examined the effect of specific parameters (i.e., electrospinning solvent, porphyrin content) on decreases in sensor brightness and oxygen sensitivity. While ultraviolet and visible excitation wavelengths exhibit poor tissue penetration, near-infrared (NIR) light much more easily penetrates tissue due to decreased scattering and absorbance by tissue chromophores. The ability to achieve NIR-activated oxygen sensing in electrospun bilayer and core-shell nanofibers has been demonstrated by using upconverting particles to locally stimulate oxygen-sensitive molecules. Finally, concerns associated with delivery have been addressed by utilizing the same sensing components in the form of polymeric core-shell particles.
John Lannutti (Advisor)
Heather Powell (Committee Member)
Jinwoo Hwang (Committee Member)
241 p.
Engineering; Materials Science
Electrospinning; oxygen sensing; upconversion; porphyrin; polymer nanofibers; photobleaching; electrospraying

Recommended Citations

Citations

  • Presley, K. F. (2018). Oxygen Sensing Electrospun Nanofibers for Biological Applications [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1531616455684609

    APA Style (7th edition)

  • Presley, Kayla. Oxygen Sensing Electrospun Nanofibers for Biological Applications. 2018. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1531616455684609.

    MLA Style (8th edition)

  • Presley, Kayla. "Oxygen Sensing Electrospun Nanofibers for Biological Applications." Doctoral dissertation, Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1531616455684609

    Chicago Manual of Style (17th edition)

osu1531616455684609
113
© 2018, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.