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The Application of Ru(II) Polypyridyl Photoinduced Ligand Exchange from Drug Delivery to Photoactivation of Fluorescent Dyes

Rohrabaugh, Thomas Nelson, Jr.
http://rave.ohiolink.edu/etdc/view?acc_num=osu1533226287168103

Abstract Details

2018, Doctor of Philosophy, Ohio State University, Chemistry.
Photoinduced ligand exchange is a phenomenon that has been observed in Ru(II) polypyridyl complexes, where upon excitation with visible light, a bond between the metal and ligand is broken, the ligand is released, and the resulting open coordination site on the metal is filled by a solvent molecule. The work herein describes the application of photoinduced ligand exchange in compounds designed to possess dual activity against cancer and other diseases in the form of a combination of photochemotherapy (PCT) and photodynamic therapy (PDT). The poor selectivity of conventional chemotherapy drugs, such as cisplatin, lead to several negative side effects. PCT and PDT agents offer an alternative to traditional chemotherapy with increased selectivity, since the compound is only active in tissue that is exposed to light. In addition, photoinduced ligand exchange can to applied to photoactivation of fluorescent dyes, such that when the dye ligand is tethered to the Ru metal center its emission quneched. Upon irradaition with visible light, the dye ligand is released or "uncaged", turning on its emission. Most of the photoactivatable dyes reported to date feature organic caging groups that require high energy UV light to release the caged molecule and activate its fluorescence. This is not ideal for biologial applications since high energy UV light can cause damage to living systems. Therefore, Ru(II)–dye complexes, were synthesized and characterized. Before photolysis, the Ru(II)-dye complexes were weakly emissive due to quenching by the Ru(II) center.
Claudia Turro (Advisor)
140 p.
Chemistry
Photoinduced ligand exchange; Ru polypyridyl complexes; Photochemotherapy; Photodynamic Therapy; Photoactivation of fluorescent dyes; Photochemistry

Recommended Citations

Citations

  • Rohrabaugh, Jr., T. N. (2018). The Application of Ru(II) Polypyridyl Photoinduced Ligand Exchange from Drug Delivery to Photoactivation of Fluorescent Dyes [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1533226287168103

    APA Style (7th edition)

  • Rohrabaugh, Jr., Thomas. The Application of Ru(II) Polypyridyl Photoinduced Ligand Exchange from Drug Delivery to Photoactivation of Fluorescent Dyes. 2018. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1533226287168103.

    MLA Style (8th edition)

  • Rohrabaugh, Jr., Thomas. "The Application of Ru(II) Polypyridyl Photoinduced Ligand Exchange from Drug Delivery to Photoactivation of Fluorescent Dyes." Doctoral dissertation, Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1533226287168103

    Chicago Manual of Style (17th edition)

osu1533226287168103
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This open access ETD is published by The Ohio State University and OhioLINK.