Skip to Main Content
 

Global Search Box

 
 
 
 

ETD Abstract Container

Abstract Header

Associations between Antimicrobial Resistance Phenotypes in Salmonella spp. and Generic E. coli among Feedlot Cattle in the US

Abstract Details

2018, Master of Public Health, Ohio State University, Public Health.
Antimicrobial resistance among pathogenic bacteria is a major public health concern, and infections of resistant organisms are often associated with increases in mortality and healthcare costs. There is much debate surrounding food animal production and its contribution to antimicrobial resistance in foodborne pathogens. It has been well-established that commensal organisms may serve as reservoirs for which pathogenic bacteria may acquire resistance determinants. This study utilizes data collected as part of the 2011 NAHMS feedlot study to investigate the associations of resistance phenotypes between Salmonella spp. and generic E. coli isolated from fecal samples from feedlot cattle. A logistic regression analysis using generalized estimating equations (GEE) to account for sample clustering was performed separately for individual and composite samples. The PROC GLIMMIX procedure was run sequentially, comparing the resistance status of the Salmonella spp. isolates to that of the generic E. coli isolates for a panel of 15 antimicrobials, as well as the ACSSuT resistance-type and multidrug resistant (MDR) categorization. Tetracycline resistance among the Salmonella spp. and E. coli isolates was significantly associated for both sample types. Among the individual samples, the odds of recovering a tetracycline-resistant Salmonella spp. isolate from a fecal sample was increased when a tetracycline-resistant generic E. coli was concurrently isolated (OR=1.688, CI, 1.043-2.734, p=0.033). This was also true for the composite samples (OR=2.042, CI, 1.089-3.829, p=0.026). However, the Holm-Bonferroni step-down procedure was implemented to account for multiple hypothesis-tests, resulting in an adjusted p-value of p=0.199 for the individual samples and p=0.130 for the composite samples. These findings may indicate an association of tetracycline-resistance between the two isolates, however a larger sample size may be necessary to determine if a statistically significant relationship actually exists.
Gregory Habing, DVM, MS, PhD (Advisor)
Wittum Thomas, MS, PhD (Committee Member)
Pennell Michael, PhD (Committee Member)
45 p.

Recommended Citations

Citations

  • Black, N. J. (2018). Associations between Antimicrobial Resistance Phenotypes in Salmonella spp. and Generic E. coli among Feedlot Cattle in the US [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1534460480971477

    APA Style (7th edition)

  • Black, Nicholas. Associations between Antimicrobial Resistance Phenotypes in Salmonella spp. and Generic E. coli among Feedlot Cattle in the US. 2018. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1534460480971477.

    MLA Style (8th edition)

  • Black, Nicholas. "Associations between Antimicrobial Resistance Phenotypes in Salmonella spp. and Generic E. coli among Feedlot Cattle in the US." Master's thesis, Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1534460480971477

    Chicago Manual of Style (17th edition)