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Carol Huseby Dissertation 11_2018.pdf (4.22 MB)

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Molecular Neuropathology in Alzheimer's Disease

Huseby, Carol
http://rave.ohiolink.edu/etdc/view?acc_num=osu1543314678552794

Abstract Details

2018, Doctor of Philosophy, Ohio State University, Biophysics.
Alzheimer’s disease affects one in ten Americans and incidences are on the increase while other leading causes of disease are declining. Alzheimer’s disease is defined by two proteinaceous lesions in brain, extracellular Aß plaques and intracellular tau neurofibrillary tangles. Tau protein is a microtubule-associated protein found abundantly expressed in neurons. Its function is to stabilize and promote microtubules and neurite outgrowth. In Alzheimer’s disease, tau protein is hyperphosphorylated and dissociates from microtubules to form aggregate filaments inside neurons disrupting the transport along axons within neurons. A remarkable aspect of the AD disease progression is the range of brain regions that are affected in a systematic, sequential manner maintaining a predictable distribution pattern of intraneuronal tau lesions varying little between individuals and an extended prodromal period. The progression of neurofibrillary tau tangle lesions in disease behaves like a prion, propagating neuron-to-neuron recruiting new tau molecules to mis-fold and continue the disease process. The mechanisms of tau protein aggregation are not clear. In this thesis I explore tau protein aggregation using biochemical methods and mathematical models and/or analysis to help clarify the aggregation mechanisms of tau protein leading to potential therapeutic strategies or targets.
Jeff Kuret (Advisor)
143 p.
Aging; Applied Mathematics; Bioinformatics; Biophysics

Recommended Citations

Citations

  • Huseby, C. (2018). Molecular Neuropathology in Alzheimer's Disease [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1543314678552794

    APA Style (7th edition)

  • Huseby, Carol. Molecular Neuropathology in Alzheimer's Disease. 2018. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1543314678552794.

    MLA Style (8th edition)

  • Huseby, Carol. "Molecular Neuropathology in Alzheimer's Disease." Doctoral dissertation, Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1543314678552794

    Chicago Manual of Style (17th edition)

osu1543314678552794
277
© 2018, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.