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The comparison of the relationship between urinary flavonoid metabolites and 1, 2 or 3 days of diet records

Pashkova, Anna
http://rave.ohiolink.edu/etdc/view?acc_num=osu1555435715311063

Abstract Details

2019, Master of Science, Ohio State University, Health and Rehabilitation Sciences.
Dietary intake plays a central role in the etiology and prevention of cancer. However, limitations of dietary assessment instruments pose significant challenges for dietary research. Thus, there is a critical need for objective, noninvasive biomarkers of dietary exposure. Literature suggests urinary flavonoid metabolites are associated with fruit and vegetable (FV) intakes, yet precise correlations between these metabolites and specific days and length of dietary record (DR) collection have yet to be elucidated. The objective of this study was to evaluate the strength of relationships between a targeted panel of urinary flavonoid metabolites with varying days and length of DR to determine optimal methodology for evaluating FV intakes. Three-day DR from 17 cancer survivors were analyzed using Nutrition Data System for Research (NDSR) to quantify FV intakes. Twenty-four hour urine samples were collected on the final day of the DR. Urinary flavonoids were quantified using high-performance liquid chromatography with diode array detection (HPLC-DAD). Correlations between the sum of 6 urinary flavonoids (μmol/L) and FV intakes (total grams) including and excluding potatoes were analyzed using: (a) sum of intakes from 3-day DR, (b) sum of intakes from 2-day DR, and (c) intakes from each day of DR separately. Total urinary flavonoid concentration was weakly-to-moderately associated with total FV intakes for 3-day, 2-day, and 1-day records (all p>0.05). When excluding potatoes, total urinary flavonoid concentration was moderately associated with total FV intakes on both 3-day (r=0.48, p=0.05) and 2-day (r=0.55, p=0.02) records. FV intakes including and excluding potatoes from records on the day preceding urine collection were moderately associated with total flavonoid concentration (r=0.49, p=0.05; r=0.55, p=0.02, respectively). A targeted panel of urinary flavonoids is most strongly associated with FV (excluding potatoes) consumed the day before and day of urine collection. These complementary assessment methods should be investigated in a larger population to further define accuracy.
Colleen Spees, PhD, RDN, LD, FAND (Advisor)
Elizabeth Grainger, PhD, RDN, LD (Committee Member)
Kristen Roberts, PhD, RDN, LD, CNSC (Committee Member)
105 p.
Nutrition
urinary flavonoids; dietary biomarkers; diet records; fruit and vegetable biomarkers

Recommended Citations

Citations

  • Pashkova, A. (2019). The comparison of the relationship between urinary flavonoid metabolites and 1, 2 or 3 days of diet records [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1555435715311063

    APA Style (7th edition)

  • Pashkova, Anna. The comparison of the relationship between urinary flavonoid metabolites and 1, 2 or 3 days of diet records. 2019. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1555435715311063.

    MLA Style (8th edition)

  • Pashkova, Anna. "The comparison of the relationship between urinary flavonoid metabolites and 1, 2 or 3 days of diet records." Master's thesis, Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1555435715311063

    Chicago Manual of Style (17th edition)

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This open access ETD is published by The Ohio State University and OhioLINK.