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Bioinspired Smart Surfaces with Switchable Wetting Properties for Droplet Manipulation and Controlled Drug Release

Qi, Lin
http://rave.ohiolink.edu/etdc/view?acc_num=osu1555584165880048

Abstract Details

2019, Doctor of Philosophy, Ohio State University, Biomedical Engineering.
Natural plant surfaces, such as lotus leaves, rice leaves, and rose petals, possess unique wetting properties. Lotus leaves contain hierarchic micro/nano-topographies with a waxy coating and exhibit isotropic and ultralow flow resistance. A water droplet can roll off the surfaces that are tilted at a small angle regardless of the tilting direction. Rose petals also own hierarchic micro/nano-topographies, but with larger characteristic dimensions. The petal surfaces possess a high water flow resistance and can pin small water droplets on the surfaces even if the surfaces are positioned vertically or upside down. On the other hand, the petal surfaces are superhydrophobic so that the droplets can move without leaving any residue. A rice leaf has linearly arranged micro/nanopapillae, which lead to anisotropic flow resistance that can move water droplets preferably along the alignment. In this dissertation, bioinspired smart surfaces are investigated to mimic the distinct wetting properties on natural plant surfaces. In-plane mechanical stretching of the smart surfaces can dynamically and repeatedly modulate the characteristic dimensions of the micro-wrinkles, and in turn switch the surface wetting properties. With proper hydrophobic treatment, the wetting properties of the smart surfaces can be switched between lotus-like and rose-like; or lotus-like and rice-like. The surface wetting states can also be changed from Cassie Baxter state to Wenzel state by mechanical straining. In order to validate the efficacy of the smart surfaces in biomedical applications, droplet-based open channel microfluidics, and strain activated drug release are established respectively. In particular, lossless droplet transfer, droplet splitting, and modulation of droplet mobility are demonstrated on the lotus-rose switchable smart surfaces. Dynamic modulation of wetting anisotropy is exhibited on the lotus-rice switchable smart surfaces. Mechanical strain activated stepwise drug release are established using the smart surfaces that switch wetting states from the Cassie Baxter state to the Wenzel state. In addition, the perspectives of future development are discussed to expand the potential applications of smart surfaces. This dissertation proposes a new type of hierarchic topographies and provides a solid technical basis for creating the next-generation bioinspired smart surface and validating the enormous potentials of such smart surfaces in biomedical applications.
Yi Zhao (Advisor)
Derek Hansford (Committee Member)
Jun Liu (Committee Member)
Kubilay Sertel (Other)
147 p.
Biomedical Engineering
biomimetic; bioinspired; smart surface; superhydrophobic; tunable wettability; lotus leaf; rose petal; rice leaf; Cassie Impregnating state; open channel microfluidics; digital microfluidics; drug release; surface wrinkle; electrospray;

Recommended Citations

Citations

  • Qi, L. (2019). Bioinspired Smart Surfaces with Switchable Wetting Properties for Droplet Manipulation and Controlled Drug Release [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1555584165880048

    APA Style (7th edition)

  • Qi, Lin. Bioinspired Smart Surfaces with Switchable Wetting Properties for Droplet Manipulation and Controlled Drug Release. 2019. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1555584165880048.

    MLA Style (8th edition)

  • Qi, Lin. "Bioinspired Smart Surfaces with Switchable Wetting Properties for Droplet Manipulation and Controlled Drug Release." Doctoral dissertation, Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1555584165880048

    Chicago Manual of Style (17th edition)

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This open access ETD is published by The Ohio State University and OhioLINK.