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Clostroides difficile Infection: Interactions Between Humans and Dogs

Collins, Sean P
http://orcid.org/0000-0002-5853-9303
http://rave.ohiolink.edu/etdc/view?acc_num=osu1557134632657158

Abstract Details

2019, Master of Science, Ohio State University, Public Health.
C. difficile is a clinically significant healthcare associated infection, but recently there has been an emergence of a new class of C. difficile infection (CDI); community-associated (CA) CDI. This presents added burden to the already significant issue. CDI is responsible for an estimated 453,000 cases and at least 29,000 deaths annually in the United States (Curry, 2017). As a spore former, it is difficult to remove from the hospital environment. C. difficile has been found in a wide variety of mammals, including dogs, and there is a potential for zoonotic transmission of C. difficile from dogs to humans. This study aimed to determine if owning a dog or owning a dog that tested positive for C. difficile increased the odds of having C. difficile. This study also examined the antibiotic resistance pattern of the C. difficile strains found in humans and dogs to see if they were the same. This study accomplished this through a robust sampling and survey method. Patients at The Ohio State University Wexner Medical Center diagnosed with CDI were asked about whether they owned a dog and provided a fecal sample if they did. PCR ribotyping and antibiotic resistance typing was used to examine the genetic relatedness of strains isolated from humans and their dogs and indistinguishable strains could represent transmission. This study provided data to support that C. difficile was not transmitted between dogs and humans.
Susan Olivo-Marston, Dr. (Advisor)
Kurt Stevenson, Dr. (Committee Chair)
40 p.
Epidemiology
C difficile; dog; PCR ribotyping; antibiotic resistance

Recommended Citations

Citations

  • Collins, S. P. (2019). Clostroides difficile Infection: Interactions Between Humans and Dogs [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1557134632657158

    APA Style (7th edition)

  • Collins, Sean. Clostroides difficile Infection: Interactions Between Humans and Dogs. 2019. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1557134632657158.

    MLA Style (8th edition)

  • Collins, Sean. "Clostroides difficile Infection: Interactions Between Humans and Dogs." Master's thesis, Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1557134632657158

    Chicago Manual of Style (17th edition)

osu1557134632657158
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This open access ETD is published by The Ohio State University and OhioLINK.