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CAB_Dissertation_Revised_071719.pdf (281.05 MB)

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Improvement of the Tissue-Engineered Vascular Graft and Discovery of a Novel Immunomodulator

Best, Cameron A
http://rave.ohiolink.edu/etdc/view?acc_num=osu1562760692281514

Abstract Details

2019, Doctor of Philosophy, Ohio State University, Biomedical Sciences.
A tissue-engineered vascular graft (TEVG) that resists stenosis and grows with its host holds great promise for the field of pediatric congenital heart surgery. This dissertation describes work designed to improve our understanding of the process of cell seeding to assemble TEVGs prior implantation, to inform computational approaches for the rational design of second-generation TEVG scaffolds, to develop methods for the creation of patient-specific TEVGs, to elucidate the natural history of TEVG stenosis and describe its spontaneous reversal, to test the hypothesis that LYST protein expression in macrophages regulates the process of neovessel stenosis and develop novel strategies to modulate its activity in vivo, and to explore the potential of anti-LYST therapy to attenuate cardiovascular fibroproliferative pathologies. The work presented is a collection of peer-reviewed publications, manuscripts under review, and unpublished works in progress spanning studies performed in mice, rats, juvenile lambs, and humans. The findings reported herein provide the foundation for the translation of a readily available, off-the-shelf TEVG with growth capacity that does not require cell seeding and identifies a potent immunomodulatory protein that represents a novel therapeutic target to improve outcomes in the field of cardiovascular surgery.
Christopher Breuer, MD (Advisor)
Jeffrey Parvin, MD, PhD (Committee Member)
Joanna Groden, PhD (Committee Member)
Ryan Roberts, MD, PhD (Committee Member)
Jordan Pober, MD, PhD (Committee Member)
319 p.
Biomedical Research
tissue-engineered vascular graft, biodegradable scaffold, cell seeding, congenital heart surgery, stenosis, LYST, innate immunity

Recommended Citations

Citations

  • Best, C. A. (2019). Improvement of the Tissue-Engineered Vascular Graft and Discovery of a Novel Immunomodulator [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1562760692281514

    APA Style (7th edition)

  • Best, Cameron. Improvement of the Tissue-Engineered Vascular Graft and Discovery of a Novel Immunomodulator . 2019. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1562760692281514.

    MLA Style (8th edition)

  • Best, Cameron. "Improvement of the Tissue-Engineered Vascular Graft and Discovery of a Novel Immunomodulator ." Doctoral dissertation, Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1562760692281514

    Chicago Manual of Style (17th edition)

osu1562760692281514
187
© 2019, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.