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Use of Nonsteroidal Anti-inflammatory Drugs Restores the Immune Responses of Geriatric Cotton Rats (Sigmodon hispidus) against Respiratory Syncytial Virus

Harder, Olivia Elyse
http://rave.ohiolink.edu/etdc/view?acc_num=osu1574677458676559

Abstract Details

2019, Master of Science, Ohio State University, Comparative and Veterinary Medicine.
Human respiratory syncytial virus (RSV) infection is often perceived as a childhood disease, but is in fact a serious health risk for adults and the elderly as well. RSV is the second most common cause of viral pneumonia in the elderly after influenza virus infection. The cotton rat (Sigmodon hispidus) is an excellent small animal model for infection with RSV due to its susceptibility to infection and similarities to human infection. We investigated in cotton rats how age affected viral clearance and immune responses and whether pharmacological intervention was possible. Our results demonstrated that virus grew to similar titers in the geriatric cotton rats as in young adult cotton rats, but had prolonged clearance rates in geriatric animals. After immunization with RSV, the geriatric cotton rats (in contrast to adult animals) were not fully protected and had minimal neutralizing antibody titers. Geriatric cotton rats also had significantly fewer RSV specific B cells when compared to adult cotton rats. Antibody-mediated depletion of cytotoxic T lymphocytes (CTL) during primary infection delayed RSV clearance, indicating a role of CTL, which, however, do not function as well in geriatric as in adult animals. Published literature suggests that the inflammatory state of the body, which increases with age, can contribute to various diseases in the elderly. Pharmacological suppression of inflammation through nonsteroidal anti-inflammatory ibuprofen resulted in faster viral clearance and complete protection after immunization, comparable to adult animals. In addition, the CTL response in the presence of ibuprofen was restored. It appears that in geriatric animals, the basic immune functions do not act as effectively as in adults animals and that anti-inflammatory therapy may restore effective immune function.
Stefan Niewiesk (Advisor)
Prosper Boyaka (Committee Member)
Mark Peeples (Committee Member)
67 p.
Aging; Comparative; Immunology; Virology
Cotton Rats; Respiratory Syncytial Virus; Aging; NSAIDs

Recommended Citations

Citations

  • Harder, O. E. (2019). Use of Nonsteroidal Anti-inflammatory Drugs Restores the Immune Responses of Geriatric Cotton Rats (Sigmodon hispidus) against Respiratory Syncytial Virus [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1574677458676559

    APA Style (7th edition)

  • Harder, Olivia. Use of Nonsteroidal Anti-inflammatory Drugs Restores the Immune Responses of Geriatric Cotton Rats (Sigmodon hispidus) against Respiratory Syncytial Virus. 2019. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1574677458676559.

    MLA Style (8th edition)

  • Harder, Olivia. "Use of Nonsteroidal Anti-inflammatory Drugs Restores the Immune Responses of Geriatric Cotton Rats (Sigmodon hispidus) against Respiratory Syncytial Virus." Master's thesis, Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1574677458676559

    Chicago Manual of Style (17th edition)

osu1574677458676559
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This open access ETD is published by The Ohio State University and OhioLINK.