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Effect of Changes to the Circadian Rhythm on Susceptibility to Noise- and Drug-Induced Hearing Losses

Harrison, Ryan T
http://rave.ohiolink.edu/etdc/view?acc_num=osu1574719906038686

Abstract Details

2019, Doctor of Philosophy, Ohio State University, Speech and Hearing Science.
Acquired hearing loss is a serious public health issue that affects a significant number of people across the world. Two of the main types of acquired hearing losses are those caused by noise and pharmaceutical drugs. Noise-induced hearing loss is typically caused by exposure to intense noise, whereas drug-induced hearing loss is a side effect of a variety of medications. Platinum-based anti-neoplastic drugs and aminoglycoside antibiotics are two drug classes that regularly have ototoxic side effects. Cisplatin and kanamycin are commonly used exemplars for these classes, respectively. Recently, there has been growing interest in determining the effects of intrinsic physiological systems on the susceptibility to these types of hearing loss. Of particular interest are the effects of the circadian rhythm. Circadian rhythms are a collection of cyclical physiological processes that repeat with a period of roughly twenty-four hours, and are found in nearly every cell and organ population in the body. They are regulated by a master clock in the hypothalamus and dictate the state of the body at a given time and how it reacts to stimuli. Using the principles of chronotolerance and chronotherapy, we investigated the effects of changing circadian rhythm phases on the susceptibility to noise-, kanamycin-, and cisplatin-induced hearing losses in a mouse model. We found that abrupt changes to the phase of the circadian rhythm in which mice are exposed to noise has no effect on the susceptibility to noise-induced hearing loss. Additionally, we found no evidence to suggest there is an effect of the circadian rhythm on susceptibility to noise at all. For the susceptibility to kanamycin-induced hearing loss, we found an effect of the circadian rhythm. Mice exposed to kanamycin just after the light to dark transition had the highest hearing thresholds, which recovered by the final test day. The same group had the highest Wave I amplitudes in auditory brainstem response testing. Finally, for susceptibility to cisplatin-induced hearing loss, we found an effect of the circadian rhythm. The mice exposed to cisplatin during dark hours showed the lowest thresholds, but there was no clear pattern between Wave I amplitudes. Overall, we conclude that there is no effect of changing circadian rhythms on noise-induced hearing loss, but that attention to the time of drug exposure is beneficial in attempting to reduce the ototoxic side effects of kanamycin or cisplatin.
Eric Bielefeld, PhD (Advisor)
Christina Roup, PhD (Committee Member)
Lawrence Feth, PhD (Committee Member)
163 p.
Audiology
hearing loss; noise; kanamycin; cisplatin; circadian rhythm; auditory brainstem response; outer hair cell; cochlea

Recommended Citations

Citations

  • Harrison, R. T. (2019). Effect of Changes to the Circadian Rhythm on Susceptibility to Noise- and Drug-Induced Hearing Losses [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1574719906038686

    APA Style (7th edition)

  • Harrison, Ryan. Effect of Changes to the Circadian Rhythm on Susceptibility to Noise- and Drug-Induced Hearing Losses. 2019. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1574719906038686.

    MLA Style (8th edition)

  • Harrison, Ryan. "Effect of Changes to the Circadian Rhythm on Susceptibility to Noise- and Drug-Induced Hearing Losses." Doctoral dissertation, Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1574719906038686

    Chicago Manual of Style (17th edition)

osu1574719906038686
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This open access ETD is published by The Ohio State University and OhioLINK.