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Chris Morgan Thesis 12-28-2019.pdf (2.38 MB)

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Biomaterial-Assisted Periosteal Tissue Expansion

Morgan, Christopher Bradley
http://rave.ohiolink.edu/etdc/view?acc_num=osu1577530934478696

Abstract Details

2020, Master of Science, Ohio State University, Materials Science and Engineering.
The clinical need for alternatives to autografts the “gold standard” in non-union bone wound healing are desperately needed. Non-unions occur with large amounts of bone loss (≥50% circumferential loss and ≥ 2cm in length1) and are common in traumatic, kinetic injuries such as explosions and car crashes. The periosteum has been shown to be vital in bone wound repair and decrease the amount of bone loss for a wound to be considered critical. Various tissue engineering techniques each with its own benefits and drawbacks have been used to treat these injuries. This experiment was conducted to create a construct that acts as a periosteal replacement in wounds lacking the tissue. Electrospun scaffolds were soaked in simulated bodily fluid (SBF) for 24 hours at 37 °C to nucleate calcium phosphate crystals onto the fibers. This polymer-ceramic scaffold was then loaded with periosteal tissue explants cut into 2mm strips and place at distances of 2mm and 4mm apart. The goal was to identify how the calcium phosphate would affect the migration of periosteal cells from the explanted tissue and speed at which the gaps were closed. The calcium phosphate was found to have no significant effect on the migration of the cells from the periosteal tissue.
Heather Powell, Dr. (Advisor)
John Lannutti, Dr. (Committee Member)
David McComb, Dr. (Committee Member)
78 p.
Materials Science

Recommended Citations

Citations

  • Morgan, C. B. (2020). Biomaterial-Assisted Periosteal Tissue Expansion [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1577530934478696

    APA Style (7th edition)

  • Morgan, Christopher . Biomaterial-Assisted Periosteal Tissue Expansion . 2020. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1577530934478696.

    MLA Style (8th edition)

  • Morgan, Christopher . "Biomaterial-Assisted Periosteal Tissue Expansion ." Master's thesis, Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1577530934478696

    Chicago Manual of Style (17th edition)

osu1577530934478696
56
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