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Heimlich Thesis 4-15-20.pdf (1.14 MB)

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Temporal Examination and Quantification of Fiber Cell Morphology and Arrangement in Chick and Mouse Lenses

Heimlich, Derek
http://rave.ohiolink.edu/etdc/view?acc_num=osu1586982635479627

Abstract Details

2020, Master of Science, Ohio State University, Vision Science.
The transparency and elasticity of the crystalline lens is a result of the configuration of regularly assembled hexagonal secondary lens fibers that are continuously added throughout the life of the lens. It is believed that maintenance of an ordered and symmetrical fiber arrangement is important to avoid pathologies such as cataracts. Despite an abundance of research dedicated to lens development, the critical processes involved in the regulation of lens fiber shape and coordination of lens fiber arrangement are unknown. For the first time, we have shown the critical timing when secondary lens fibers transition from disorganized secondary lens fiber formation to an ordered and regular packing of newly formed fibers in mice and chicken animal models. Additionally, we have demonstrated an important role for contractile junctional proteins such as Rho-kinase, Shroom3, and p120-catenin in the maintenance of lens fiber morphology and organization. This research defines crucial time points and critical protein mediators that can be expanded upon in future research dedicated to further understanding lens development and mechanisms responsible for providing the lens with its unique structural characteristics required for function.
Timothy Plageman (Advisor)
Heather Chandler (Committee Member)
Andrew Hartwick (Committee Member)
63 p.
Developmental Biology; Ophthalmology
Lens Fiber Morphology; Shroom3; p-120 catenin; rho-kinase; Lens development

Recommended Citations

Citations

  • Heimlich, D. (2020). Temporal Examination and Quantification of Fiber Cell Morphology and Arrangement in Chick and Mouse Lenses [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1586982635479627

    APA Style (7th edition)

  • Heimlich, Derek. Temporal Examination and Quantification of Fiber Cell Morphology and Arrangement in Chick and Mouse Lenses. 2020. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1586982635479627.

    MLA Style (8th edition)

  • Heimlich, Derek. "Temporal Examination and Quantification of Fiber Cell Morphology and Arrangement in Chick and Mouse Lenses." Master's thesis, Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1586982635479627

    Chicago Manual of Style (17th edition)

osu1586982635479627
170
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