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Well-being and Inflammation in Interstitial Lung Disease

Rodriguez, Ihsan

Abstract Details

2021, Master of Science, Ohio State University, Psychology.
As noted by Swigris and colleagues (2015), health-related quality of life (HRQoL) among individuals diagnosed with Interstitial Lung Disease (ILD) is known to impact functioning across a range of dimensions. To date, research on HRQoL in ILD has focused on physiological functioning, symptoms, functional status, and psychological functioning. However, quality of life (QoL) may include additional relevant domains such as social support and health perceptions. This study was designed to provide a more holistic perspective of QoL among individuals with ILD, by assessing six quality of life domains (biological and physiological functioning, symptom status, functional status, health perceptions, social support, and psychological functioning) identified in the Cleary and Wilson HRQoL model (1995). Forty participants with ILD were recruited from patients being treated in an outpatient clinic for pulmonary diseases. Participants completed HRQoL questionnaires and blood sampling for analysis of inflammatory biomarkers. Primary QoL measures included illness-specific and generic physical and mental quality of life. The primary approach to data analyses included an examination of the interrelationships among HRQoL domains, followed by hierarchical regression analyses to determine whether perceptual, social, or psychological variables predicted additional variance in QoL when controlling for select physiological variables. A final analysis compared QoL outcomes across ILD diagnostic groups to determine whether greater disease burden was experienced by those with faster compared to slower illness progression. Results indicated that illness-specific and generic QoL outcomes were associated with the six HRQoL dimensions. Novel findings included a positive association of generic mental QoL with social support, as well as positive associations of health perceptions with illness-specific QOL and with generic physical and mental QoL. Domains of illness perceptions and psychological functioning predicted both illness-specific and generic QoL when controlling for physiological variables, highlighting the importance of illness perceptions and psychological functioning for QoL among individuals with ILD.
Charles Emery (Advisor)
117 p.

Recommended Citations

Citations

  • Rodriguez, I. (2021). Well-being and Inflammation in Interstitial Lung Disease [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1619031719578262

    APA Style (7th edition)

  • Rodriguez, Ihsan. Well-being and Inflammation in Interstitial Lung Disease. 2021. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1619031719578262.

    MLA Style (8th edition)

  • Rodriguez, Ihsan. "Well-being and Inflammation in Interstitial Lung Disease." Master's thesis, Ohio State University, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1619031719578262

    Chicago Manual of Style (17th edition)