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toledo1234981048.pdf (3.94 MB)
ETD Abstract Container
Abstract Header
The Effect of Exercise on Endothelial Function in Postprandial Lipemia
Author Info
Thompson, Benjamin Charles
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=toledo1234981048
Abstract Details
Year and Degree
2008, Doctor of Philosophy, University of Toledo, Exercise Science.
Abstract
Physical activity can prevent atherosclerotic progression which is characterized by an impaired flow-mediated dilation (FMD) response. Using the postprandial state as a surrogate, some of the mechanisms associated with endothelial dysfunction and physical activity are becoming better understood.
PURPOSE:
To determine the endothelium-dependent response (FMD) to a high fat meal (HFM) prior to a bout of moderate exercise and to see if the shear stress stimulus is appropriate for the FMD response.
METHODS:
9 healthy men [32±8 yrs, 80.5±21.8 kg, 178.4±9.6 cm, 25.3±4.9 kg•m
-2
(means±SD)] completed 4 randomized experimental conditions: 1) Control, 2) Meal only, 3) Exercise only, 4) Meal and Exercise combined. FMD was measured with B-Mode ultrasonography and mean blood velocity with Doppler velocimetry both in the left brachial artery at baseline, 2 hrs, 3hrs, and 4hrs post-baseline measurement.
RESULTS:
Baseline brachial artery diameter was not different between the 4 experimental conditions. The percent change in FMD2, FMD3, and FMD4 (4.6±2.0%, 3.9±1.6%, 4.0±2.0%, respectively) were significantly lower (P<0.05) compared to FMD1 (6.4±2.0%) in the Meal only condition. When expressed as the percent change from FMD1 in Meal and Exercise, a decrease in endothelial function following the meal (-29±26%) was attenuated by the bout of moderate exercise (+22±67%, P<0.05). There were no main effects or condition-by-time interactions for shear stress in any of the experimental conditions.
CONCLUSION:
These results indicate that the consumption of a high fat meal significantly impairs endothelial function and that a bout of moderate exercise performed after the meal can counteract these negative effects. In addition, it appears that the FMD response is independent of the shear stress stimulus suggesting the presence of another mechanism which impairs endothelial function.
Committee
Barry Scheuermann, PhD (Committee Chair)
Leonard Greninger, PhD (Committee Member)
Danny Pincivero, PhD (Committee Member)
Suzanne Wambold, PhD (Committee Member)
Pages
144 p.
Subject Headings
Biology
;
Nutrition
Keywords
flow-mediated dilation
;
brachial artery
;
postprandial
;
endothelium-dependent
;
shear stress
Recommended Citations
Refworks
EndNote
RIS
Mendeley
Citations
Thompson, B. C. (2008).
The Effect of Exercise on Endothelial Function in Postprandial Lipemia
[Doctoral dissertation, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1234981048
APA Style (7th edition)
Thompson, Benjamin.
The Effect of Exercise on Endothelial Function in Postprandial Lipemia.
2008. University of Toledo, Doctoral dissertation.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=toledo1234981048.
MLA Style (8th edition)
Thompson, Benjamin. "The Effect of Exercise on Endothelial Function in Postprandial Lipemia." Doctoral dissertation, University of Toledo, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1234981048
Chicago Manual of Style (17th edition)
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Document number:
toledo1234981048
Download Count:
1,095
Copyright Info
© 2008, all rights reserved.
This open access ETD is published by University of Toledo and OhioLINK.