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ETD Abstract Container

Abstract Header

The Effect of Ethanol on Three Types of Ependymal Cilia in The Brain Lateral Ventricle

Al Omran , Alzahra J
http://rave.ohiolink.edu/etdc/view?acc_num=toledo1434979511

Abstract Details

2015, Master of Science, University of Toledo, Pharmaceutical Science.
Ependymal cells are multiciliated cells that line the central canal of the brain ventricles and the spinal cord, contributing to cerebral spinal fluid (CSF) circulation. Motile cilia dysfunction can result in hydrocephalous due to the hindrance of CSF movement. Though, the cause of hydrocephalus has been intensively studied, we are the first to report three distinct groups of cilia responsible for the flow of CSF through the lateral ventricle. We classified the cilia based upon the beating frequency and movement angle into three types that localize in certain areas within the lateral ventricle. Moreover, we were able to localize hydin, a unique gene that is expressed in the central pair microtubules of motile cilia. Mutations in hydin are known to cause hydrocephalous. We also provide visual proof, through immunofluorescence, of polycystin-2 existing in the ependymal cilia. Our studies further show that ethanol can reduce the beating frequency of all three types, in both ex-vivo and in-vivo ethanol treatments.
Wissam AbouAlaiwi (Committee Chair)
Youssef Sari (Committee Member)
Zahoor Shah (Committee Member)
58 p.
Pharmacology

Recommended Citations

Citations

  • Al Omran , A. J. (2015). The Effect of Ethanol on Three Types of Ependymal Cilia in The Brain Lateral Ventricle [Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1434979511

    APA Style (7th edition)

  • Al Omran , Alzahra . The Effect of Ethanol on Three Types of Ependymal Cilia in The Brain Lateral Ventricle. 2015. University of Toledo, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=toledo1434979511.

    MLA Style (8th edition)

  • Al Omran , Alzahra . "The Effect of Ethanol on Three Types of Ependymal Cilia in The Brain Lateral Ventricle." Master's thesis, University of Toledo, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1434979511

    Chicago Manual of Style (17th edition)

toledo1434979511
209
© 2015, all rights reserved.
This open access ETD is published by University of Toledo and OhioLINK.