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JOthesis.pdf (12.72 MB)
ETD Abstract Container
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Importance of the a,ß-Unsaturated Ketone in Methuosis-Inducing Compounds
Author Info
Offenbacher, Jennifer M
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=toledo1449828250
Abstract Details
Year and Degree
2015, Master of Science, University of Toledo, Medicinal Chemistry.
Abstract
Methuosis is a novel type of nonapoptic cell death in which vacuoles form and swell until the cell membrane bursts. Several indole-based chalcones have been found to induce methuosis. These indole-based chalcones contain a,ß-unsaturated ketones which may undergo Michael addition. However, the heterocycles on either side of the a,ß-unsaturated ketone have a less studied effect on Michael addition. Also, the metabolites of methuosis-inducing chalcones are reduced forms of the a,ß-unsaturated ketone. These metabolites are synthesized as a part of this thesis. Synthesis of analogues on the pyridinyl ring, primarily extending the nitrogen out of the ring and modifying the electronics is reported herein.
Committee
Paul Erhardt, Ph.D. (Committee Chair)
Jeffery Sarver, Ph.D. (Committee Member)
Christopher Trabbic, Ph.D. (Committee Member)
Subject Headings
Analytical Chemistry
;
Chemistry
;
Organic Chemistry
;
Pharmacy Sciences
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Citations
Offenbacher, J. M. (2015).
Importance of the a,ß-Unsaturated Ketone in Methuosis-Inducing Compounds
[Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1449828250
APA Style (7th edition)
Offenbacher, Jennifer.
Importance of the a,ß-Unsaturated Ketone in Methuosis-Inducing Compounds.
2015. University of Toledo, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=toledo1449828250.
MLA Style (8th edition)
Offenbacher, Jennifer. "Importance of the a,ß-Unsaturated Ketone in Methuosis-Inducing Compounds." Master's thesis, University of Toledo, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1449828250
Chicago Manual of Style (17th edition)
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Document number:
toledo1449828250
Download Count:
537
Copyright Info
© 2015, all rights reserved.
This open access ETD is published by University of Toledo and OhioLINK.