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Dissertation Final Esakov.pdf (8.5 MB)

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Characterization of a Novel Pre-Diabetic Murine Model for Type 1 Diabetes

Esakov, Emily
http://rave.ohiolink.edu/etdc/view?acc_num=toledo148111253829366

Abstract Details

2016, Doctor of Philosophy, University of Toledo, Medicinal Chemistry.
It has been shown in the non-obese diabetic (NOD) mouse model that type 1 diabetes (T1D) is an autoimmune disease characterized by insulitis and T cell-mediated destruction of pancreatic islet beta cells. The insulin receptor (IR) is a chemotactic receptor capable of driving T cell movement in response to insulin. To this end, characterizing IR expression is of key importance for understanding the pathogenesis of diabetes. T cells may be driven to infiltrate pancreatic islets due to a high level of IR on their surface. The purpose of this project is to phenotype the transgenic BL/6-CD3FLAGmIR (non-diabetic) mouse model to better understand the role of increased IR on the CD3+ T cell surface in relation to pancreatic insulitis. This animal model shows onset of insulitis, but animals do not become diabetic making them an efficient model to study trafficking of CD3+ T cells from the spleen to the pancreas as the altered T cells are FLAG tagged. If IR expression is established as a mechanism to move T cells into islets, then down regulation or blocking of IR expression specifically in T cells will provide a new therapeutic target to block cell movement into the pancreas, thus preventing T1D.
Marcia McInerney (Committee Chair)
Katherine Wall (Committee Member)
Hermann Von Grafenstein (Committee Member)
Andrea Kalinoski (Committee Member)
125 p.
Immunology; Pharmacy Sciences

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Citations

  • Esakov, E. (2016). Characterization of a Novel Pre-Diabetic Murine Model for Type 1 Diabetes [Doctoral dissertation, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=toledo148111253829366

    APA Style (7th edition)

  • Esakov, Emily. Characterization of a Novel Pre-Diabetic Murine Model for Type 1 Diabetes. 2016. University of Toledo, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=toledo148111253829366.

    MLA Style (8th edition)

  • Esakov, Emily. "Characterization of a Novel Pre-Diabetic Murine Model for Type 1 Diabetes." Doctoral dissertation, University of Toledo, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=toledo148111253829366

    Chicago Manual of Style (17th edition)

toledo148111253829366
138
© 2016, all rights reserved.
This open access ETD is published by University of Toledo and OhioLINK.