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Evaluation of Polycardanol as an Antifouling Coating: An Experimental and Theoretical Assessment of Protein-Polymer Interactions

Patania, Michelle
http://rave.ohiolink.edu/etdc/view?acc_num=toledo148132605001625

Abstract Details

2016, Master of Science, University of Toledo, Chemical Engineering.
Protein adhesion to medical devices can interfere with their proper function. Once a layer of proteins is attached, this makes it easier for bacteria to attach, which can result in infection. Additionally, when blood proteins adsorb to a biomaterial, this facilitates the clot forming process, which can cause failure of the medical device. For these reasons, it is important to understand protein interaction with surfaces and to develop biomaterial surfaces that resist protein adhesion. In this study, the antifouling properties of polycardanol surfaces toward proteins are investigated. Theoretical methods are useful to predict and compare antifouling properties of surfaces. This study applies the Derjaguin-Landau-Verwey-Overbeek (DLVO) theory to predict protein adhesion to various polycardanol surfaces and controls such as glass and polyvinyl chloride (PVC). The DLVO theory provides interaction energy profiles for a system, in this case, a protein and surface in an aqueous medium at biological conditions. The proteins used in this study are serum albumin and fibrinogen. Experimental data for protein adhesion to polycardanol and control surfaces is then obtained by use of protein kits. Additives to polycardanol, including a fluoropolymer and polyethylene glycol, will be used to modify polycardanol surface properties, and the effect on protein adhesion will be assessed. The DLVO theory suggested that more hydrophilic surfaces, or those that have a greater affinity for water, have a greater energy barrier to serum albumin adhesion. Application of the theory shows that glass and polycardanol containing PEG should show resistance to protein adhesion. The experimental protein kit results, however, suggest that a monolayer of protein attaches within minutes to all the surfaces studied, and no significant antifouling behavior is shown for the experiments in this study. It is recommended that polycardanol surfaces containing greater additive content be investigated. Additionally, accounting for other considerations such as surface roughness and hydration effects may help explain the experimental results.
Dong-Shik Kim (Committee Chair)
Yakov Lapitsky (Committee Member)
Constance Schall (Committee Member)
111 p.
Chemical Engineering
protein adhesion; DLVO theory; polycardanol; antifouling

Recommended Citations

Citations

  • Patania, M. (2016). Evaluation of Polycardanol as an Antifouling Coating: An Experimental and Theoretical Assessment of Protein-Polymer Interactions [Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=toledo148132605001625

    APA Style (7th edition)

  • Patania, Michelle. Evaluation of Polycardanol as an Antifouling Coating: An Experimental and Theoretical Assessment of Protein-Polymer Interactions. 2016. University of Toledo, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=toledo148132605001625.

    MLA Style (8th edition)

  • Patania, Michelle. "Evaluation of Polycardanol as an Antifouling Coating: An Experimental and Theoretical Assessment of Protein-Polymer Interactions." Master's thesis, University of Toledo, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=toledo148132605001625

    Chicago Manual of Style (17th edition)

toledo148132605001625
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© 2016, all rights reserved.
This open access ETD is published by University of Toledo and OhioLINK.