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Saad Thesis.pdf (3.54 MB)
ETD Abstract Container
Abstract Header
Synthesis and Validation of a C5 '-Pseudouridinyl Radical Precursor
Author Info
Alqarni, Saad Ali
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=toledo1501602637102475
Abstract Details
Year and Degree
2017, Master of Science, University of Toledo, Medicinal Chemistry.
Abstract
Pseudouridine (¿) is the most abundant modified nucleosides in RNA and the only naturally occurring C-nucleoside. It is enzymatically generated in RNA and has variable functions that are not fully understood. Pseudouridine synthesis is enzyme catalyzed. Defects in these enzymes cause multisystem disorders because of a decrease in pseudouridine formation. On the other hand, it was shown that pseudouridine synthesis is upregulated under stress conditions in constitutive sites and new sites. The goal of this project is to synthesize a suitable radical precursor for pseudouridine to study the effect of oxidative stress on RNA. The data comparison between the effect of oxidative stress on pseudouridine and on other nucleosides possessing C-N glycosyl bonds would give valuable information about the function of pseudouridine.
Committee
Amanda Bryant-Friedrich (Committee Chair)
Isaac Schiefer (Committee Member)
Donald Ronning (Committee Member)
Subject Headings
Organic Chemistry
Keywords
Pseudouridine oxidative stress RNA
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Citations
Alqarni, S. A. (2017).
Synthesis and Validation of a C5 '-Pseudouridinyl Radical Precursor
[Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1501602637102475
APA Style (7th edition)
Alqarni, Saad.
Synthesis and Validation of a C5 '-Pseudouridinyl Radical Precursor.
2017. University of Toledo, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=toledo1501602637102475.
MLA Style (8th edition)
Alqarni, Saad. "Synthesis and Validation of a C5 '-Pseudouridinyl Radical Precursor." Master's thesis, University of Toledo, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1501602637102475
Chicago Manual of Style (17th edition)
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Document number:
toledo1501602637102475
Download Count:
296
Copyright Info
© , some rights reserved.
Synthesis and Validation of a C5 '-Pseudouridinyl Radical Precursor by Saad Ali Alqarni is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by University of Toledo and OhioLINK.