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The Atypical Centriole of Human and Beetle Sperm

Fishman, Emily Lillian
http://rave.ohiolink.edu/etdc/view?acc_num=toledo1556808522272757

Abstract Details

2019, Doctor of Philosophy, University of Toledo, Biology (Cell-Molecular Biology).
For the last century, scientists have accepted the idea that, during fertilization, the sperm contributes relatively little to the developing embryo. The egg provides most of the cytoplasmic contents that the embryo will need, with one major exception: a subcellular organelle known as the centrioles. Most dividing cells, including those of the embryo, need precisely two centrioles for normal development, and therefore they undergo a controlled duplication and inheritance scheme. In most animals, the first cell of the embryo inherits its centrioles solely from the sperm. However, in mammals and insects, it was thought that the sperm contributed only one centriole, which created a mystery surrounding how the embryo acquires its two centrioles. In light of the discovery that the sperm of fruit flies contains an additional centriole that deviates from the highly conserved typical centriole structure, here we present the discovery of a functional, yet atypical, second centriole structure in beetles, bulls, and humans. This work suggests a universal hypothesis for centriole inheritance where number is conserved, but structure and protein composition is not. This work seeks to resolve the mystery of the origin of centrioles and makes hypotheses about the reason for their structural divergence.
Tomer Avidor-Reiss, Ph.D. (Committee Chair)
Lirim Shemshedini, Ph.D. (Committee Chair)
Rafael Garcia-Mata, Ph.D. (Committee Member)
Hinds Terry, Ph.D. (Committee Member)
Hill Jennifer, Ph.D. (Committee Member)
Song-Tao Liu, Ph.D. (Committee Member)
Biology; Cellular Biology; Developmental Biology
Sperm; Centriole; Atypical Centriole; Bovine; human; beetle; tribolium; zygote; centrosome; centrosome reduction

Recommended Citations

Citations

  • Fishman, E. L. (2019). The Atypical Centriole of Human and Beetle Sperm [Doctoral dissertation, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1556808522272757

    APA Style (7th edition)

  • Fishman, Emily. The Atypical Centriole of Human and Beetle Sperm. 2019. University of Toledo, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=toledo1556808522272757.

    MLA Style (8th edition)

  • Fishman, Emily. "The Atypical Centriole of Human and Beetle Sperm." Doctoral dissertation, University of Toledo, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1556808522272757

    Chicago Manual of Style (17th edition)

toledo1556808522272757
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© 2019, all rights reserved.
This open access ETD is published by University of Toledo and OhioLINK.