Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


ucin1020113729.pdf (1.51 MB)

ETD Abstract Container

Abstract Header

EVALUATING THE EFFECTIVENESS OF A HAND-WASHING INTERVENTION ON DERMAL ABSORPTION OF POLYCYCLIC AROMATIC HYDROCARBONS, DNA ADDUCTS, AND 1-HYDROXYPYRENE LEVELS IN AUTOMOTIVE MECHANIC TRAINEES

BOOTH-JONES, ANGELA DAMITA
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1020113729

Abstract Details

2002, PhD, University of Cincinnati, Medicine : Environmental Health Sciences.
Participants completed an exposure questionnaire upon study entry and provided an urine, blood and hand wipe sample. The participants received hand-cleaning products during the study and completed a hand washing frequency questionnaire at periodic visits to the schools for the collection of urine and hand wipe samples. This group was followed for 2-6 months. Several endpoints were measured including dermal exposure to PAHs, and subsequent DNA adducts in leukocytes and 1-hydroxypyrene levels in urine. The self-reported performance of eight major engine tasks was assessed by questionnaire; these tasks were analyzed separately and as combined categories according to upper engine (i.e. valves, lifters, and pistons repairs), lower engine (i.e. bearings, rings, crankshafts, and oil pump repairs), and oil change. Dermal exposure to PAHs was measured by levels of pyrene, benzo[a]pyrene, and benz[a]anthracene (B[a]A) in hand wipe samples and they varied from 0.027 to 6.67 µg/cm2. Pyrene (PYR) contamination in hand wipe samples did decrease following the intervention. An association of engine tasks and PAH exposure was evaluated and seen for PYR and B[a]A. The greatest UGEO exposure occurred while doing engine work. The levels of DNA adducts in leukocytes were 8.43 and 2.58 RAL in the pre- and post-intervention samples, respectively. Reductions in adduct levels following the intervention was seen in several samples. This study demonstrated that automotive mechanic trainees did have dermal exposures to PAHs in UGEO, and that through a hand washing intervention and education, these exposures may be reduced.
Dr. Glenn Talaska (Advisor)
171 p.
Health Sciences, General
polycylic aromatic hydrocarbons (PAHS); hand washing intervention; dermal absorption; DNA adducts in blood; 1-hydroxypyrene in urine

Recommended Citations

Citations

  • BOOTH-JONES, A. D. (2002). EVALUATING THE EFFECTIVENESS OF A HAND-WASHING INTERVENTION ON DERMAL ABSORPTION OF POLYCYCLIC AROMATIC HYDROCARBONS, DNA ADDUCTS, AND 1-HYDROXYPYRENE LEVELS IN AUTOMOTIVE MECHANIC TRAINEES [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1020113729

    APA Style (7th edition)

  • BOOTH-JONES, ANGELA. EVALUATING THE EFFECTIVENESS OF A HAND-WASHING INTERVENTION ON DERMAL ABSORPTION OF POLYCYCLIC AROMATIC HYDROCARBONS, DNA ADDUCTS, AND 1-HYDROXYPYRENE LEVELS IN AUTOMOTIVE MECHANIC TRAINEES. 2002. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1020113729.

    MLA Style (8th edition)

  • BOOTH-JONES, ANGELA. "EVALUATING THE EFFECTIVENESS OF A HAND-WASHING INTERVENTION ON DERMAL ABSORPTION OF POLYCYCLIC AROMATIC HYDROCARBONS, DNA ADDUCTS, AND 1-HYDROXYPYRENE LEVELS IN AUTOMOTIVE MECHANIC TRAINEES." Doctoral dissertation, University of Cincinnati, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1020113729

    Chicago Manual of Style (17th edition)

ucin1020113729
2,722
© 2002, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.