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A STUDY OF THE EFFECT OF SINGLE NUCLEOTIDE POLYMORPHISMS IN HUMAN GENOME ON THE SECONDARY STRUCTURE OF PROTEINS

Aswathanarayanan, Subramanian

Abstract Details

2002, MS, University of Cincinnati, Engineering : Computer Science.
Geneticists throughout the world are involved in deciphering the genetic code of various organisms including that of human beings. With the discovery of more single nucleotide polymorphisms (SNPs) everyday and the role played by them in human diseases, a lot of attention is being paid to understand their effect on the structure and biological function of proteins. This will not only help us in understanding the human biology better, but will also provide us with a way to fight genetic and hereditary diseases. In this thesis we have studied the effect of SNPs on the helix structure, which is one of the most important structures of all. The study has been done by taking in to consideration, the hydrophobicity of amino acids involved. Overall, our results indicate that most of the SNPs are structure preserving in nature. We have also investigated if change of secondary structure, especially helix, in genes might be the responsible for disease in the human body. Our results indicate that a break in helical structure of a gene might change its biological function.
Yizong Cheng (Advisor)
45 p.

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Citations

  • Aswathanarayanan, S. (2002). A STUDY OF THE EFFECT OF SINGLE NUCLEOTIDE POLYMORPHISMS IN HUMAN GENOME ON THE SECONDARY STRUCTURE OF PROTEINS [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1024675762

    APA Style (7th edition)

  • Aswathanarayanan, Subramanian. A STUDY OF THE EFFECT OF SINGLE NUCLEOTIDE POLYMORPHISMS IN HUMAN GENOME ON THE SECONDARY STRUCTURE OF PROTEINS. 2002. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1024675762.

    MLA Style (8th edition)

  • Aswathanarayanan, Subramanian. "A STUDY OF THE EFFECT OF SINGLE NUCLEOTIDE POLYMORPHISMS IN HUMAN GENOME ON THE SECONDARY STRUCTURE OF PROTEINS." Master's thesis, University of Cincinnati, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1024675762

    Chicago Manual of Style (17th edition)