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APPLICABILITY OF MASS SPECTROMETRY TO DETECT COELUTING IMPURITIES IN HIGH PERFORMANCE LIQUID CHROMATOGRAPHY

ANTONOVICH, ROBERT STEVEN
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1029170713

Abstract Details

2002, MS, University of Cincinnati, Pharmacy : Pharmaceutical Sciences.
n array of pharmaceutical compounds and impurities were used to investigate the applicability of atmospheric pressure ionization mass spectrometry (MS) to routinely detect coeluting impurities in HPLC (i.e. peak purity). Four drugs were individually tested against their related impurity set utilizing a straightforward HPLC-MS peak purity strategy. For the investigated set, which represents 24 unique drug-impurity permutations, 75% of the coeluting impurities were detected at levels <1.0%, including one-third at 0.1%. Factors that affect the applicability of this peak purity approach are also discussed.
Dr. Pankaj B. Desai (Advisor)
pharmaceutical analysis; peak purity

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Citations

  • ANTONOVICH, R. S. (2002). APPLICABILITY OF MASS SPECTROMETRY TO DETECT COELUTING IMPURITIES IN HIGH PERFORMANCE LIQUID CHROMATOGRAPHY [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1029170713

    APA Style (7th edition)

  • ANTONOVICH, ROBERT. APPLICABILITY OF MASS SPECTROMETRY TO DETECT COELUTING IMPURITIES IN HIGH PERFORMANCE LIQUID CHROMATOGRAPHY. 2002. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1029170713.

    MLA Style (8th edition)

  • ANTONOVICH, ROBERT. "APPLICABILITY OF MASS SPECTROMETRY TO DETECT COELUTING IMPURITIES IN HIGH PERFORMANCE LIQUID CHROMATOGRAPHY." Master's thesis, University of Cincinnati, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1029170713

    Chicago Manual of Style (17th edition)

ucin1029170713
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© 2002, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.