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MATERNAL DIABETES MELLITUS AND POTENTIALLY OTOTOXIC MEDICATIONS ON THE NEONATE: A RETROSPECTIVE STUDY

SUTHERLAND, BILLIE BROOKE

Abstract Details

2003, MA, University of Cincinnati, Allied Health Sciences : Communication Sciences and Disorders.
Objective: This thesis looked at the incidence of ototoxic drug treatment and the hearing status of infants born to mothers with diabetes mellitus. This population is expected to be prone to ototoxic drug exposure due to generalized infections and poor fluid excretion (Martinez-Frais, 1998; Aberg, 2001; Farell, 2001). That is possibly due to the poor neonatal cellular metabolism effect on infants born to mothers with maternal diabetes. Specifically, the use of the aminoglycoside, gentamicin and the loop diuretic, furosemide were examined. Typically, damage from aminoglycosides begins in row one of the outer hair cells within the high frequency region of the basal cochlea and often progresses to the low frequency region of the apex. Concern arises when the areas of the cochlea necessary for hearing and subsequently the development of speech are harmed (Kalkanis, 2002). Methods: This retrospective research study used data from the medical records of 100 mothers with diabetes mellitus and their infants. The data collection and review was conducted at the Good Samaritan Hospital in Cincinnati, Ohio. Their audiology files provided us with documentation of otoacoustic emissions (OAE), auditory brainstem response (ABR) screening outcomes and high-risk registry data. All data was placed into a database to allow for strict patient confidentiality. The study included children born at the hospital between January 1, 2000 and May 1, 2002. The Diabetics group includes mothers with Maternal Diabetes Mellitus (MD) (Types I and II) and their infants tested for hearing impairment between January 2000 and April 2002. Results: Out of the four children on aminoglycosides, three were considered to be very low birth weight and the fourth was considered to be high birth weight. Three out of the four children on aminoglycosides failed the OAE and were referred for ABR. Also, three out of the four children on aminoglycosides were considered to be premature. A total of 4/100 (4%) were exposed to aminoglycosides. 2/4 (50%) were in the NICU 1/4 (25%) were in the well-baby nursery and the other child was not listed as NICU or well-baby.
Dr. Susan Stanton (Advisor)
44 p.

Recommended Citations

Citations

  • SUTHERLAND, B. B. (2003). MATERNAL DIABETES MELLITUS AND POTENTIALLY OTOTOXIC MEDICATIONS ON THE NEONATE: A RETROSPECTIVE STUDY [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1061236026

    APA Style (7th edition)

  • SUTHERLAND, BILLIE. MATERNAL DIABETES MELLITUS AND POTENTIALLY OTOTOXIC MEDICATIONS ON THE NEONATE: A RETROSPECTIVE STUDY. 2003. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1061236026.

    MLA Style (8th edition)

  • SUTHERLAND, BILLIE. "MATERNAL DIABETES MELLITUS AND POTENTIALLY OTOTOXIC MEDICATIONS ON THE NEONATE: A RETROSPECTIVE STUDY." Master's thesis, University of Cincinnati, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1061236026

    Chicago Manual of Style (17th edition)