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ROLE OF THE AHR IN POLYBROMINATED BIPHENYL-INDUCED DEVELOPMENTAL TOXICITY

MILLER, KEVIN ANTHONY

Abstract Details

2003, MS, University of Cincinnati, Medicine : Environmental Health Sciences.
PBBs are known to cause negative health effects in humans and in animals. It is unknown if these effects are mediated by an underlying genetic component of the AHR phenotype. In this study, we examined the developmental effects of both coplanar and noncoplanar PBBs on mouse lines having both high and low affinity AHR phenotype with C57BL/6J background. We determined a coplanar PBB high-affinity AHR-dependent neonatal lethality and immunotoxicity, coupled with the induction of CYP1A1 in embryonic liver and brain at gestational day 18.
Dr. Daniel W. Nebert (Advisor)
57 p.

Recommended Citations

Citations

  • MILLER, K. A. (2003). ROLE OF THE AHR IN POLYBROMINATED BIPHENYL-INDUCED DEVELOPMENTAL TOXICITY [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1069702913

    APA Style (7th edition)

  • MILLER, KEVIN. ROLE OF THE AHR IN POLYBROMINATED BIPHENYL-INDUCED DEVELOPMENTAL TOXICITY. 2003. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1069702913.

    MLA Style (8th edition)

  • MILLER, KEVIN. "ROLE OF THE AHR IN POLYBROMINATED BIPHENYL-INDUCED DEVELOPMENTAL TOXICITY." Master's thesis, University of Cincinnati, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1069702913

    Chicago Manual of Style (17th edition)