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DEMOGRAPHIC ANALYSIS OF ESOPHAGITIS: A POPULATION-BASED STUDY

NOEL, RICHARD JOSEPH
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1085675249

Abstract Details

2004, MS, University of Cincinnati, Medicine : Epidemiology (Environmental Health).
Eosinophilic esophagitis (EE) refers to esophageal inflammation with marked tissue eosinophilia that does not respond to acid suppression therapy. Patients may have a variety of symptoms that mimic gastroesophageal reflux disease, but vomiting and dysphagia are the most common at presentation. We report on the descriptive epidemiology of a large population with EE. METHODS: With IRB approval, a clinical database was queried for patients with EE biopsy diagnosis, as defined as mucosal eosinophilia with >24 eosinophils per HPF, and proliferative changes with thickening of the basal layer and papillary lengthening. Date of the initial EE diagnosis, demographic information, and clinical information were recorded. Population data from the 2000 U.S. Census was obtained for incidence calculations in Hamilton County, Ohio, a population with a single pediatric hospital and pediatric GI practice. RESULTS: The search identified 315 subjects diagnosed between Feb. 1991 and Jan. 2004 from 25 states. Age at diagnosis was 8.9 +/- 6.1 years (mean +/- stdev) and the population was 72.2% male. Only 2.8% of cases were diagnosed prior to the year 2000. 103 subjects formed a subpopulation that resided within Hamilton County at the time of diagnosis. Two of these were diagnosed prior to 2000; the remainder has an age at diagnosis of 10.5 +/- 5.4 years (mean +/- stdev) and a male predominance (70.9%). Based on these data, the prevalence of EE in Hamilton County's pediatric population is 4 per 10,000 and the yearly incidence is approximately 1 in 10,000. The incidence has increased yearly between the years 2000-2003. CONCLUSIONS: The incidence of EE is approximately 1 per 10,000/yr and appears to be increasing in a single county. EE is an increasingly common disease and should be considered in the differential diagnosis of patients with GERD symptoms not responsive to acid suppression therapy.
Dr. Ralph Buncher (Advisor)
30 p.
eosinophil; esophagitis; pediatric; allergy; Hamilton; Cincinnati

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Citations

  • NOEL, R. J. (2004). DEMOGRAPHIC ANALYSIS OF ESOPHAGITIS: A POPULATION-BASED STUDY [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1085675249

    APA Style (7th edition)

  • NOEL, RICHARD. DEMOGRAPHIC ANALYSIS OF ESOPHAGITIS: A POPULATION-BASED STUDY. 2004. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1085675249.

    MLA Style (8th edition)

  • NOEL, RICHARD. "DEMOGRAPHIC ANALYSIS OF ESOPHAGITIS: A POPULATION-BASED STUDY." Master's thesis, University of Cincinnati, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1085675249

    Chicago Manual of Style (17th edition)

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© 2004, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.