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Convective-Diffusive Transport of Drugs for Intravitreal Injection and Controlled Release Implant

Park, Juyoung

Abstract Details

2004, MS, University of Cincinnati, Engineering : Mechanical Engineering.
Vitreoretinal diseases are currently being treated by intravitreal injection and controlled release implant. It is critical to know the drug distribution within the eye for adequate treatment of the diseases following these administrative methods. The vitreous diffusivity of drugs and vitreous outflow can play a significant role in drug distribution. Thus, the objective of this research is to: 1) compare the drug distribution for intravitreal injection and controlled release implant, 2) compare the drug distribution in the healthy eye with the pathophysiological eye having increased vitreous outflows, and 3) evaluate the coupled effects of vitreous outflows and diffusivities. A finite element method was applied to determine drug distribution by convective-diffusive transport processes using a 3D eye model. The implant having an equivalent amount of drug with intravitreal injection released drugs with a constant flux over a time period of 15 hrs. The implant reduced peak concentration about 40% and increased therapeutic time about 20% for the drug having 6×10-6 cm2/s of vitreous diffusivity, when compared with that of intravitreal injection for various vitreous outflows. As vitreous outflow increased from 0 to 1 µL/min, the drug half-life increased by 0.4 hrs for high vitreous diffusivity (1×10-5 cm2/s), whereas it decreased by 79.1 hrs for low vitreous diffusivity (1×10-7 cm2/s). Therefore, the implant can reduce the toxicity in vivo and result in a sustained release of the drug. Additionally, the convective-diffusive transfer and washout effect of drugs should be considered in the design of delivery strategies to treat vitreoretinal diseases. The present benchmark study allows for the prediction of drug distribution in the eye for the combined effects among drug delivery methods, diffusion of drug, and convection in the eye.
Dr. Rupak Banerjee (Advisor)
86 p.

Recommended Citations

Citations

  • Park, J. (2004). Convective-Diffusive Transport of Drugs for Intravitreal Injection and Controlled Release Implant [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1099444270

    APA Style (7th edition)

  • Park, Juyoung. Convective-Diffusive Transport of Drugs for Intravitreal Injection and Controlled Release Implant. 2004. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1099444270.

    MLA Style (8th edition)

  • Park, Juyoung. "Convective-Diffusive Transport of Drugs for Intravitreal Injection and Controlled Release Implant." Master's thesis, University of Cincinnati, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1099444270

    Chicago Manual of Style (17th edition)