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ucin1109343185.pdf (1.03 MB)
ETD Abstract Container
Abstract Header
POROUS INORGANIC SUPPORTED LIQUID MEMBRANES FOR USE IN ION CHANNELING
Author Info
GLADDING, SARAH M
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1109343185
Abstract Details
Year and Degree
2005, MS, University of Cincinnati, Engineering : Chemical Engineering.
Abstract
The objective of this research was to use a porous inorganic material to support a biological membrane, which could be used in ion channeling. The support consisted of a gamma-alumina core covered with a thin silica layer. The hydrophilic surface of the silica was then modified with C18 (octadecyltrichlorosilane) in order to make the surface hydrophobic. A lipid layer was then deposited, in which the hydrophobic tails of the lipid layer interacted with the hydrophobic carbon chains of the C18 to create a bilayer, which served as a host for the protein, Gramicidin D. Experimental results show that the inorganic support did provide stability for the biomembrane, as well as provided a reservoir to store material for ion exchange. Ion exchange did occur, especially after the addition of the protein ion channels, and this exchange was measured using a pH change test.
Committee
Dr. Jerry Lin (Advisor)
Pages
86 p.
Subject Headings
Engineering, Chemical
Keywords
inorganic membranes
;
biological membranes
;
lipids
;
proteins
;
ion channels
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Citations
GLADDING, S. M. (2005).
POROUS INORGANIC SUPPORTED LIQUID MEMBRANES FOR USE IN ION CHANNELING
[Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1109343185
APA Style (7th edition)
GLADDING, SARAH.
POROUS INORGANIC SUPPORTED LIQUID MEMBRANES FOR USE IN ION CHANNELING.
2005. University of Cincinnati, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1109343185.
MLA Style (8th edition)
GLADDING, SARAH. "POROUS INORGANIC SUPPORTED LIQUID MEMBRANES FOR USE IN ION CHANNELING." Master's thesis, University of Cincinnati, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1109343185
Chicago Manual of Style (17th edition)
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Document number:
ucin1109343185
Download Count:
1,121
Copyright Info
© 2005, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.