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ucin1147872866.pdf (250.32 KB)
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Twelve Month Outcome of Adolescents with Bipolar Disorder Following First-Hospitalization for a Manic or Mixed Episode
Author Info
DelBello, Melissa P
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1147872866
Abstract Details
Year and Degree
2006, MS, University of Cincinnati, Medicine : Epidemiology (Environmental Health).
Abstract
Objective: Although adolescent-onset bipolar disorder is associated with significant morbidity there have been few prospective outcome studies of this population. The aim of this study was to examine the 12-month outcome of adolescents with bipolar disorder following their initial hospitalization for a manic or mixed episode. Method: Bipolar adolescents (N=71) were recruited during their first hospitalization for a manic or mixed episode and were evaluated using diagnostic, symptomatic, and functional assessments. Patients were also evaluated at 1, 4, 8, and 12 months after hospitalization to assess syndromic, symptomatic, and functional outcomes. Predictors of each type of outcome were identified. Results: Kaplan-Meier estimates of the cumulative probabilities of syndromal, symptomatic, and functional recovery, and syndromic relapse (in adolescents who experienced syndromal recovery) during the first 12-months following initial hospitalization were 0.86, 0.43, 0.41, and 0.48, respectively. Only 35% of bipolar adolescents reported full medication adherence. Individual predictors of syndromic recovery included the absence of co-occurring attention deficit/hyperactivity disorder (ADHD), anxiety disorders, and disruptive behavior disorders, as well as, full psychotropic medication adherence and higher socioeconomic levels. Treatment with an antidepressant and co-occurring alcohol use disorders predicted syndromic relapse. Boys were more than twice as likely as girls to experience symptomatic recovery. Although no predictors of overall functional recovery were identified, predictors of specific domains of functional recovery were explored. Conclusions: Most bipolar adolescents experienced syndromic recovery following first hospitalization. However, rates of symptomatic and functional recoveries were much lower. Future studies examining effective treatment strategies for bipolar youth with co-occurring disorder and investigating the factors that contribute to the development of substance use disorders and treatment adherence in bipolar youth are necessary to improve outcome.
Committee
Dr. Rakesh Shukla (Advisor)
Pages
40 p.
Subject Headings
Psychology, Clinical
Keywords
Bipolar disorder
;
outcome
;
adolescents
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Citations
DelBello, M. P. (2006).
Twelve Month Outcome of Adolescents with Bipolar Disorder Following First-Hospitalization for a Manic or Mixed Episode
[Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1147872866
APA Style (7th edition)
DelBello, Melissa.
Twelve Month Outcome of Adolescents with Bipolar Disorder Following First-Hospitalization for a Manic or Mixed Episode.
2006. University of Cincinnati, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1147872866.
MLA Style (8th edition)
DelBello, Melissa. "Twelve Month Outcome of Adolescents with Bipolar Disorder Following First-Hospitalization for a Manic or Mixed Episode." Master's thesis, University of Cincinnati, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1147872866
Chicago Manual of Style (17th edition)
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Document number:
ucin1147872866
Download Count:
1,070
Copyright Info
© 2006, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.