Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


ucin1155831060.pdf (797.86 KB)

ETD Abstract Container

Abstract Header

Involvement of Rac GTPase in p53-deficiency mediated lymphomagenesis

Ni, Wenjun
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1155831060

Abstract Details

2006, MS, University of Cincinnati, Medicine : Molecular and Developmental Biology.
My studies are based on the hypothesis that Rac GTPase signaling contributes to the p53 deficiency-mediated tumorigenesis through a functional connection of Rac with the p53-regulated cell growth and survival network. Combined methods of dominant negative Rac1 expression and pharmacologic treatment with a Rac-specific small molecule inhibitor, NSC23766, were applied. In human BL41 and mouse J3D cells in which p53 is defective, p53 functional expression caused a reduction of Rac1-GTP level. Expression of N17Rac1 mutant or treatment with NSC23766 resulted in decreased Rac1 activity accompanied by decreased proliferation of these cells. The suppression of lymphoma cell proliferation by Rac1 inhibition was associated with increased apoptosis and decreased S-phase transition, as well as reduced signaling activities of Rac-downstream effectors PAK1 and AKT. These results suggest Rac1 activity is inversely regulated by p53 in the lymphoma cells, and that targeting Rac-signaling pathway may be beneficial in suppressing lymphomagenesis associated with p53-pathway deficiency.
Yi Zheng (Advisor)
35 p.
Health Sciences, General

Recommended Citations

Citations

  • Ni, W. (2006). Involvement of Rac GTPase in p53-deficiency mediated lymphomagenesis [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1155831060

    APA Style (7th edition)

  • Ni, Wenjun. Involvement of Rac GTPase in p53-deficiency mediated lymphomagenesis. 2006. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1155831060.

    MLA Style (8th edition)

  • Ni, Wenjun. "Involvement of Rac GTPase in p53-deficiency mediated lymphomagenesis." Master's thesis, University of Cincinnati, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1155831060

    Chicago Manual of Style (17th edition)

ucin1155831060
510
© 2006, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.