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Environmental Tobacco Smoke and IL-4 Polymorphism (C-589T) Gene: Environment Interaction Increases Risk of Wheezing in African-American Infants: The Cincinnati Childhood Allergy and Air Polllution Study (CCAAPS)

Smith, Andrew M.

Abstract Details

2006, MS, University of Cincinnati, Medicine : Epidemiology (Environmental Health).
Background: Children exposed to environmental tobacco smoke (ETS) have increased asthma exacerbations. IL-4 C-589T and IL-13 C-1112T single nucleotide polymorphisms are associated with enhanced production of respective cytokines and asthma phenotypes. Increased IL-4 and IL-13 cytokine levels reported in smokers suggest a potential gene-environment interaction. Objective: The purpose of this study was to determine if infants exposed to ETS having the IL-4 or IL-13 gene polymorphisms were at increased risk of infantile wheezing. Methods: A prospective birth cohort of 758 infants born to atopic parents was evaluated annually by a questionnaire, physical examination, and skin prick testing. DNA samples from 560 children were genotyped for IL-4 C-589T and IL-13 C-1112T polymorphisms. Results: The interaction of exposure to high levels of ETS and the CT/TT genotypes for IL-4 C-589T showed a significant association with wheezing without a cold (OR: 10.84; 95% CI: 1.12-104.64, p=0.04) in African-American infants but was not significant in non-African-Americans.
Dr. Grace LeMasters (Advisor)
36 p.

Recommended Citations

Citations

  • Smith, A. M. (2006). Environmental Tobacco Smoke and IL-4 Polymorphism (C-589T) Gene: Environment Interaction Increases Risk of Wheezing in African-American Infants: The Cincinnati Childhood Allergy and Air Polllution Study (CCAAPS) [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1163515177

    APA Style (7th edition)

  • Smith, Andrew. Environmental Tobacco Smoke and IL-4 Polymorphism (C-589T) Gene: Environment Interaction Increases Risk of Wheezing in African-American Infants: The Cincinnati Childhood Allergy and Air Polllution Study (CCAAPS). 2006. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1163515177.

    MLA Style (8th edition)

  • Smith, Andrew. "Environmental Tobacco Smoke and IL-4 Polymorphism (C-589T) Gene: Environment Interaction Increases Risk of Wheezing in African-American Infants: The Cincinnati Childhood Allergy and Air Polllution Study (CCAAPS)." Master's thesis, University of Cincinnati, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1163515177

    Chicago Manual of Style (17th edition)