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ucin1172356377.pdf (474.8 KB)
ETD Abstract Container
Abstract Header
ROLE OF N-ACETYL CYSTEINE IN PREVENTING AGE-RELATED HEARING LOSS
Author Info
KUO, MING-WEN
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1172356377
Abstract Details
Year and Degree
2007, MA, University of Cincinnati, Allied Health Sciences : Audiology.
Abstract
A free radical scavenger, n-acetyl cysteine (NAC), was studied to see if it reduced the age-related hearing loss, presbycusis, on the C57BL/6J mouse strain. Two groups of newborn mice were obtained from Jackson Lab. After obtaining baseline hearing thresholds using Auditory Brainstem Response (ABR), one group took NAC in their daily water while the other did not take the treatment. The average thresholds of each group were compared every month to determine the effects of NAC on hearing and cochlear function. In addition, the cochlear hair cells of each mouse were processed histologically to assess the degree of inner and outer hair cell loss in the NAC and Control Groups. Statistical analyses of the ABR and cochleogram indicate no statistically significant difference for the main effects of treatment between groups. These findings suggest the following possibilities that NAC may not affect presbycusis; the NAC levels used in this study, 200 mg/kg, may not significantly reduce presbycusis in the B6 mice; the presbycusis studied on the B6 mice may not be ROS mediated.
Committee
Dr. Susan Stanton (Advisor)
Pages
58 p.
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Citations
KUO, M.-W. (2007).
ROLE OF N-ACETYL CYSTEINE IN PREVENTING AGE-RELATED HEARING LOSS
[Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1172356377
APA Style (7th edition)
KUO, MING-WEN.
ROLE OF N-ACETYL CYSTEINE IN PREVENTING AGE-RELATED HEARING LOSS.
2007. University of Cincinnati, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1172356377.
MLA Style (8th edition)
KUO, MING-WEN. "ROLE OF N-ACETYL CYSTEINE IN PREVENTING AGE-RELATED HEARING LOSS." Master's thesis, University of Cincinnati, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1172356377
Chicago Manual of Style (17th edition)
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Document number:
ucin1172356377
Download Count:
731
Copyright Info
© 2007, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.