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Coronary Artherosclerosis in Systemic Sclerosis: A Cross-Sectional Pilot Study of Cases and Controls

Khurma, Vandana
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1179353380

Abstract Details

2007, MS, University of Cincinnati, Medicine : Epidemiology (Environmental Health).
Objectives: 1) Determine the prevalence of subclinical coronary atherosclerosis (CA) in patients with systemic sclerosis (SSc) 2) evaluate serum proinflammatory HDL (piHDL) and transforming growth factor-Β1 (TGF-Β1) levels as potential novel markers of atherosclerotic risk in SSc. Methods: Cross-sectional study of 17 patients with SSc and 17 matched controls. Measurements included coronary calcium score; lipid profile; serum levels of high-sensitivity C-reactive protein, homocysteine, piHDL, and TGF-Β1. Results: Coronary calcium was found in 12 participants (9/17 SSc, 3/17 controls, p=0.03). The mean CCS in subjects with SSc was significantly greater compared with controls (p = 0.003). Mean values for serum homocysteine and TGF-Β1 levels were significantly greater in patients with SSc (p < 0.05). Five patients with SSc (29%), but no controls had detectable levels of piHDL (p=0.06). Conclusions: Rates of subclinical CA are greater in patients with SSc compared with controls. These findings should be confirmed in a larger study.
Dr. Joel Tsevat (Advisor)
31 p.
Health Sciences, Immunology
systemic sclerosis; atherosclerosis; proinflammatory HDL; transforming growth factor-beta

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Citations

  • Khurma, V. (2007). Coronary Artherosclerosis in Systemic Sclerosis: A Cross-Sectional Pilot Study of Cases and Controls [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1179353380

    APA Style (7th edition)

  • Khurma, Vandana. Coronary Artherosclerosis in Systemic Sclerosis: A Cross-Sectional Pilot Study of Cases and Controls. 2007. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1179353380.

    MLA Style (8th edition)

  • Khurma, Vandana. "Coronary Artherosclerosis in Systemic Sclerosis: A Cross-Sectional Pilot Study of Cases and Controls." Master's thesis, University of Cincinnati, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1179353380

    Chicago Manual of Style (17th edition)

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© 2007, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.