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LIQUID-CORE CAPSULES VIA INTERFACIAL POLYMERIZATION AND ALTERNATING COPOLYMERIZATION

WU, DAN
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1179427662

Abstract Details

2007, PhD, University of Cincinnati, Engineering : Chemical Engineering.
Liquid-core capsules have wide-ranging applications in the high efficiency encapsulation and controlled delivery of drugs, dyes, enzymes, and many other substrates. These important applications have driven the rapid development of innovative techniques. Here, a direct and scalable approach was presented for encapsulating sub-micron liquid (oil or aqueous) drops within uniform <100 nm thick polymer shells through the free-radical alternating copolymerization of hydrophobic and hydrophilic monomers at interfaces. Shell thickness and overall capsule size can be finely tuned by adjusting monomer concentration and the processing conditions used in preparing the starting miniemulsion drops. The general principle of this interfacial free-radical alternating copolymerization has many potential applications extending beyond the preparation of liquid-core capsules and into other established nanotechnologies where the preponderance of interfaces accentuates the significance of this polymerization technique. Having successfully demonstrated the preparation of liquid-core capsules through interfacial free radical alternating copolymerization, we studied the properties of these amphiphilic alternating copolymers in aqueous solution. We reported for the first time the generation of self-assembled polymer vesicles via amphiphilic alternating copolymers containing hydrophobic maleate esters and hydrophilic polyhydroxy vinyl ethers. Another example of the preparation of liquid-core capsules via direct interfacial polymerization was demonstrated. We presented a direct approach to encapsulate sub-micron oil or aqueous microspheres by interfacial reaction on oil-in-water miniemulsion or water-in-oil inverse miniemulsion templates. O/W miniemulsions or W/O inverse miniemulsions were stabilized by the commercially available triblock copolymers, Pluronic. The formation of oil-core or aqueous-core (poly(ethylene oxide)/silica capsules was confirmed by TEM observations. The principle and concept behind this technique are informative and have broad potential applications in the fields of encapsulation and controlled release.
Carlos Co (Advisor)
145 p.
Engineering, Chemical
Alternating Copolymer; Encapsulation; Capsules; Miniemulsion Polymerization; Hollow Spheres; Particles; Vesicles; Nanocapsules; Fabraction

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Citations

  • WU, D. (2007). LIQUID-CORE CAPSULES VIA INTERFACIAL POLYMERIZATION AND ALTERNATING COPOLYMERIZATION [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1179427662

    APA Style (7th edition)

  • WU, DAN. LIQUID-CORE CAPSULES VIA INTERFACIAL POLYMERIZATION AND ALTERNATING COPOLYMERIZATION. 2007. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1179427662.

    MLA Style (8th edition)

  • WU, DAN. "LIQUID-CORE CAPSULES VIA INTERFACIAL POLYMERIZATION AND ALTERNATING COPOLYMERIZATION." Doctoral dissertation, University of Cincinnati, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1179427662

    Chicago Manual of Style (17th edition)

ucin1179427662
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© 2007, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.