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Land-Use Regression Modeling of Diesel Exhaust Particles and Allergic and Respiratory Disease in Children

Ryan, Patrick H.
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1182437289

Abstract Details

2007, PhD, University of Cincinnati, Medicine : Epidemiology (Environmental Health).
Asthma is the most common chronic disease of childhood affecting 12% of the children in the United States. The increase in allergic disease and asthma in recent decades may be related to environmental exposures including air pollution, aeroallergens, and endotoxin. In particular, diesel exhaust particulates (DEP) have been shown to increase allergic response and generate reactive oxygen species (ROS) upon exposure. The study hypothesis is that exposure to DEP during early childhood in the presence of other immunologic and inflammatory stimuli will significantly increase the development of allergic respiratory disease. The first aim was to develop and validate a land-use regression (LUR) model of DEP exposure for the greater Cincinnati area. The second aim was to estimate cumulative exposure to DEP at ages 6, 12, 24, and 36 months of children in the CCAAPS cohort. The third aim was to assess the relationship between DEP exposure and the prevalence of persistent aeroallergen sensitization and wheezing at age 36 months. Exposure to outdoor aeroallergens and indoor endotoxin were examined as potential modifiers of the relationship between DEP and the outcomes. Air samples of DEP at 27 sites in the greater Cincinnati area were used to develop a LUR model. The model included elevation, truck intensity, bus routes, and wind direction as significant variables to predict DEP. The average daily level of DEP at the homes, daycares, and other locations where CCAAPS children were reported to spend time was estimated by the LUR model. Cumulative exposure to DEP as early as age 12 months was associated with increased persistent allergic wheezing at age 36 months (2.1[1.0 – 4.3]), but not with persistent non-allergic wheeze. Exposure to high levels of endotoxin had an additive effect with DEP exposure on persistent wheeze (n = 82), persistent allergic wheeze (n = 42), and persistent non-allergic wheeze (n = 40) (4.1 [1.5-11.7], 3.4 [0.8 – 14.1], 4.1 [0.9 – 17.8], respectively). Hence, we have shown that exposure to DEP in the first year of life is associated with the development of persistent allergic wheezing at age 3 and this relationship is potentiated by indoor environmental exposures.
Dr. Grace LeMasters (Advisor)
146 p.
Health Sciences, Public Health

Recommended Citations

Citations

  • Ryan, P. H. (2007). Land-Use Regression Modeling of Diesel Exhaust Particles and Allergic and Respiratory Disease in Children [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1182437289

    APA Style (7th edition)

  • Ryan, Patrick. Land-Use Regression Modeling of Diesel Exhaust Particles and Allergic and Respiratory Disease in Children. 2007. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1182437289.

    MLA Style (8th edition)

  • Ryan, Patrick. "Land-Use Regression Modeling of Diesel Exhaust Particles and Allergic and Respiratory Disease in Children." Doctoral dissertation, University of Cincinnati, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1182437289

    Chicago Manual of Style (17th edition)

ucin1182437289
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© 2007, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.