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Factors Associated with Ventilator-Associated Pneumonia Recurrence in the Surgical Intensive Care Unit

Lu, Erika J.
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1186952471

Abstract Details

2007, MS, University of Cincinnati, Medicine : Epidemiology (Environmental Health).
Objective: To determine predisposing factors and outcomes for recurrent ventilator associated pneumonia (VAP). Design: Retrospective review. Patients: All adult surgical patients mechanically ventilated more than 48 hours between January 2000 and December 2004 were evaluated. VAP was defined as greater than or equal to 10,000 colony forming units/mL in a bronchoalveolar lavage or protected catheter lavage, and recurrence as a positive quantitative culture more than 4 days after initiation of antibiotics. Main Outcome Measures: We analyzed potential risk factors for recurrence, including initial pathogen, APACHE II scores, age, white blood cell count, presence of trauma, and duration of hospital stay before diagnosis. Results: Eighty four of 177 patients (48%) with confirmed VAP developed recurrence, with 68% involving methicillin-resistant S. aureus or nonfermenting gram-negative bacilli. APACHE II score, duration of hospital stay, and age were associated with recurrence (OR 1.06, p=0.04; OR 1.03, p=0.04; OR 1.02, p=0.03). Conclusions: There is a high rate of VAP recurrence in the surgical population with the majority involving drug-resistant organisms. Treatment should include coverage for these pathogens.
Dr. Paul Succop (Advisor)
24 p.
ventilator associated pneumonia; recurrence; drug resistance; surgical intensive care

Recommended Citations

Citations

  • Lu, E. J. (2007). Factors Associated with Ventilator-Associated Pneumonia Recurrence in the Surgical Intensive Care Unit [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1186952471

    APA Style (7th edition)

  • Lu, Erika. Factors Associated with Ventilator-Associated Pneumonia Recurrence in the Surgical Intensive Care Unit. 2007. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1186952471.

    MLA Style (8th edition)

  • Lu, Erika. "Factors Associated with Ventilator-Associated Pneumonia Recurrence in the Surgical Intensive Care Unit." Master's thesis, University of Cincinnati, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1186952471

    Chicago Manual of Style (17th edition)

ucin1186952471
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© 2007, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.