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A SPIRALLY-ROLLED FLEXIBLE POLYMER TUBE INTEGRATED WITH MICROSENSORS AND MICROFLUIDIC DEVICES FOR MULTIFUNCTIONAL SMART MICROCATHETERS

LI, CHUNYAN
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1196111658

Abstract Details

2007, PhD, University of Cincinnati, Engineering : Electrical Engineering.
In this research work, a flexible polymer lab-on-a-tube integrated with spirally-rolled physical/biochemical microsensors and microfluidic devices has been designed, fabricated and characterized for in situ measuring physiological/metabolic data and enhanced drug delivery in a catheter application. This new approach provides a unique way to assemble multiple microsensors and microfluidic devices both inside and outside the flexible polymer tube using standard microfabrication methods, while avoiding most challenging wiring and assembling problems associated with previous methods. Furthermore, this new tube-type platform maintains catheter inherent lumen potency for in situ drug delivery or inserting medical tools through it. In realizing the flexible polymer lab-on-a-tube for a smart catheter, first, a new spirally-rolled tube-type platform has been developed and characterized. It has been aimed to develop a new functional ‘catheter’ with required dimension, axial, flexural and torsional rigidities for various applications, and also works as a platform to mount multiple microsensors and microfluidic devices. This spirally-rolled polymer tube can be easily assembled at the tip of the conventional microcatheters due to its structural affinity or work as a free-standing catheter. As functional components of the spirally-rolled polymer tube, flexible physical and biochemical microsensors on the Kapton film, flexible tactile sensors based on PVDF-TrFE piezoelectric copolymer, and flexible Parylene microchannels, which are embedded in the tube wall, have been successfully fabricated and characterized. Flexible temperature sensor (RTD), flow rate sensor (hot film anemometry), oxygen biosensor (amperometric sensor) and glucose biosensor (amperometric sensor) have been fabricated and fully integrated both inside and outside the spirally-rolled polymer tubes with various diameters. The fabricated microsensors showed good performances not only in a planar configuration but also in a spirally-rolled configuration. To solve the visual and tactile limitations caused by the nature of catheterization, innovative bump and dome shape PVDF-TrFE films with different dimensions were successfully fabricated by a new mold transfer method and tested as flexible tactile sensors. PVDF-TrFE film works as a functional flexible substrate and developed tactile sensors have shown high sensitivity and strong mechanical strength for microcatheter applications. Flexible Parylene microchannels have been fabricated by a rapid and low cost stamp-and-stick fabrication method and successfully assembled on the polymer tube by spirally-rolling. This unique spiral structure with microchannels shows a potential capability as a basic component of the effective catheter-based drug delivery system. Two new models of flexible polymer lab-on-a-tube have been designed by combining flexible microsensors and microfluidic devices together in this work. Much more advanced and effective ‘smart’ catheter models have been demonstrated for cardiovascular disease and brain tumor monitoring and treatment. This flexible polymer lab-on-a-tube system provides a generic platform for developing patient-specific ‘smart’ microcatheters that incorporate with microsensors, microactuators, wireless signal communication modules and microfluidic devices tailored for the patient’s unique condition.
Dr. Chong H. Ahn (Advisor)
174 p.
smart microcatheter; lab-on-a-tube; flexible microsensor; flexible microchannel

Recommended Citations

Citations

  • LI, C. (2007). A SPIRALLY-ROLLED FLEXIBLE POLYMER TUBE INTEGRATED WITH MICROSENSORS AND MICROFLUIDIC DEVICES FOR MULTIFUNCTIONAL SMART MICROCATHETERS [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1196111658

    APA Style (7th edition)

  • LI, CHUNYAN. A SPIRALLY-ROLLED FLEXIBLE POLYMER TUBE INTEGRATED WITH MICROSENSORS AND MICROFLUIDIC DEVICES FOR MULTIFUNCTIONAL SMART MICROCATHETERS. 2007. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1196111658.

    MLA Style (8th edition)

  • LI, CHUNYAN. "A SPIRALLY-ROLLED FLEXIBLE POLYMER TUBE INTEGRATED WITH MICROSENSORS AND MICROFLUIDIC DEVICES FOR MULTIFUNCTIONAL SMART MICROCATHETERS." Doctoral dissertation, University of Cincinnati, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1196111658

    Chicago Manual of Style (17th edition)

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© 2007, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.