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SONOFLUIDIC MICRO-SYSTEMS FOR PRECISION-CONTROLLED IN-VIVO DRUG DELIVERY

THACKER, JAMES H

Abstract Details

2007, MS, University of Cincinnati, Engineering : Electrical Engineering.
In orthopaedics, current methods of drug delivery are technologically primitive in that they limit the control over dosing parameters including amplitude, frequency, and chronology of delivery. The research in this thesis works toward a sonofluidic delivery system that would allow control over these parameters. A drug-containing textile would be placed in-vivo at the delivery site, remaining non-permeated until the application of ultrasound. With ultrasound, the ambient fluid would permeate the textile, mix with the enclosed product, and release the product via diffusion. Chronologically separate delivery may be achieved by adjusting parameters of the textile and applied ultrasonic signal. This would allow delivery of product in controlled quantities, thus maximizing product absorption. This thesis discusses the design, fabrication, and testing of six generations of sonofluidic devices, along with future research directions, where recommendations are made for the design of a device conforming more to the standards of a commercial prototype.
Dr. Jason Heikenfeld (Advisor)
102 p.

Recommended Citations

Citations

  • THACKER, J. H. (2007). SONOFLUIDIC MICRO-SYSTEMS FOR PRECISION-CONTROLLED IN-VIVO DRUG DELIVERY [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1196178160

    APA Style (7th edition)

  • THACKER, JAMES. SONOFLUIDIC MICRO-SYSTEMS FOR PRECISION-CONTROLLED IN-VIVO DRUG DELIVERY. 2007. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1196178160.

    MLA Style (8th edition)

  • THACKER, JAMES. "SONOFLUIDIC MICRO-SYSTEMS FOR PRECISION-CONTROLLED IN-VIVO DRUG DELIVERY." Master's thesis, University of Cincinnati, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1196178160

    Chicago Manual of Style (17th edition)