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ucin1196178160.pdf (3.17 MB)
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SONOFLUIDIC MICRO-SYSTEMS FOR PRECISION-CONTROLLED IN-VIVO DRUG DELIVERY
Author Info
THACKER, JAMES H
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1196178160
Abstract Details
Year and Degree
2007, MS, University of Cincinnati, Engineering : Electrical Engineering.
Abstract
In orthopaedics, current methods of drug delivery are technologically primitive in that they limit the control over dosing parameters including amplitude, frequency, and chronology of delivery. The research in this thesis works toward a sonofluidic delivery system that would allow control over these parameters. A drug-containing textile would be placed in-vivo at the delivery site, remaining non-permeated until the application of ultrasound. With ultrasound, the ambient fluid would permeate the textile, mix with the enclosed product, and release the product via diffusion. Chronologically separate delivery may be achieved by adjusting parameters of the textile and applied ultrasonic signal. This would allow delivery of product in controlled quantities, thus maximizing product absorption. This thesis discusses the design, fabrication, and testing of six generations of sonofluidic devices, along with future research directions, where recommendations are made for the design of a device conforming more to the standards of a commercial prototype.
Committee
Dr. Jason Heikenfeld (Advisor)
Pages
102 p.
Keywords
Sonofluidics
;
Biomems
;
Microfluidics
;
Ultrasound
;
Sonocapillary
;
Laplace
;
Orthopaedic Drug Delivery
;
Orthopedic Drub Delivery
;
BMP2
;
BMP7
;
Growth Factors
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Citations
THACKER, J. H. (2007).
SONOFLUIDIC MICRO-SYSTEMS FOR PRECISION-CONTROLLED IN-VIVO DRUG DELIVERY
[Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1196178160
APA Style (7th edition)
THACKER, JAMES.
SONOFLUIDIC MICRO-SYSTEMS FOR PRECISION-CONTROLLED IN-VIVO DRUG DELIVERY.
2007. University of Cincinnati, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1196178160.
MLA Style (8th edition)
THACKER, JAMES. "SONOFLUIDIC MICRO-SYSTEMS FOR PRECISION-CONTROLLED IN-VIVO DRUG DELIVERY." Master's thesis, University of Cincinnati, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1196178160
Chicago Manual of Style (17th edition)
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Document number:
ucin1196178160
Download Count:
522
Copyright Info
© 2007, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.