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CREATION OF A BIOPHYSICAL MODEL OF A STRIATAL DORSAL LATERAL MEDIUM SPINY NEURON INCORPORATING DENDRITIC EXCITATION BY NMDA AND AMPA RECEPTOR MODELS

BIDDELL, KEVIN MICHAEL
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1196211076

Abstract Details

2007, PhD, University of Cincinnati, Engineering : Biomedical Engineering.
The medium spiny neurons of the ventral medial (VM) and dorsal-lateral (DL) striatum play different roles in the basal ganglia; these differences include NMDA receptor time characteristics and NMDA/AMPA receptor concentration ratio. To facilitate the advancement seen in other areas of computational modeling, a publicly available biophysical model that standardizes in NEURON the research of medium spiny neurons (MSN’s) of the dorsal lateral striatum is necessary. To assess the hypothesis that differences in VM and DL striatal MSN’s can be studied by measuring the individual and cumulative effects of NMDA and AMPA receptors, existing biophysical computational models of medium spiny neurons were translated, expanded, and integrated. Action potentials and individual currents of two model MSN’s were compared with simulated NMDA and AMPA receptors using parameters set at published nucleus accumbens values and values adapted to fit the dorsal lateral striatum. The combined effect of the time characteristics of the NMDA receptor and the NMDA/AMPA receptor ratio affected how the modeled behaved. Overall model excitation increased when NMDA and AMPA receptors were stimulated in distal dendrites compared to proximal excitation. Second, with significant decreases in time constants came an increase in action potential firing synchronicity. The dorsal lateral and ventral medial striatum of the sensory motor and limbic basal ganglia respectively are different, including the time constants, and the role these neuron types play in normal, abnormal and diseased process are independent. In building the model used to test this hypothesis, multiple theories of striatal behavior have been tied together in a comprehendible, consistent, and testable manner. This work now lends itself to generating and testing new hypotheses. The implications of the two hypotheses already generated are also discussed.
Dr. Jeffery Johnson (Advisor)
224 p.
computer simulation,; computational neuroscience,; biopyhsics

Recommended Citations

Citations

  • BIDDELL, K. M. (2007). CREATION OF A BIOPHYSICAL MODEL OF A STRIATAL DORSAL LATERAL MEDIUM SPINY NEURON INCORPORATING DENDRITIC EXCITATION BY NMDA AND AMPA RECEPTOR MODELS [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1196211076

    APA Style (7th edition)

  • BIDDELL, KEVIN. CREATION OF A BIOPHYSICAL MODEL OF A STRIATAL DORSAL LATERAL MEDIUM SPINY NEURON INCORPORATING DENDRITIC EXCITATION BY NMDA AND AMPA RECEPTOR MODELS. 2007. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1196211076.

    MLA Style (8th edition)

  • BIDDELL, KEVIN. "CREATION OF A BIOPHYSICAL MODEL OF A STRIATAL DORSAL LATERAL MEDIUM SPINY NEURON INCORPORATING DENDRITIC EXCITATION BY NMDA AND AMPA RECEPTOR MODELS." Doctoral dissertation, University of Cincinnati, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1196211076

    Chicago Manual of Style (17th edition)

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© 2007, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.