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The changes of antibody levels to MsgC variants over time in HIV-infected men

Djawe, Kpandja
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1211893247

Abstract Details

2008, MS, University of Cincinnati, Medicine : Environmental Health.
The Major Surface Glycoprotein (Msg) is a crucial protein complex in Pneumocystis pathogenicity and is involved in host-organism interaction. Our objectives are to analyze the antibody responses to four MsgC clones in three patient groups and to determine the factors associated with PcP death. Tobit regression model was used to analyze the mean antibody differences. We found higher odds of antibodies rise to MsgC1, MsgC8, and MsgC9 if the first AIDS-defining disease was PcP versus others (OR [95%CI]: 6.2 [1.1-35.4], the same). The mean antibodies to MsgC8 at last clinic visit was significantly higher in PcP patients compared to colonized and non-colonized patients (11.0 vs 2.3, 2.6, respectively). PcP patients had a highly rate of previous PcP diagnoses (73%) compared to the other groups (43% each). Our results suggest that PcP death was associated with higher antibody levels to MsgC8, and previous episode of PcP.
Ralph Buncher (Advisor)
Linda Levin (Committee Member)
Susan Pinney (Committee Member)
Peter Walzer (Committee Member)
27 p.
Biomedical Research; Immunology

Recommended Citations

Citations

  • Djawe, K. (2008). The changes of antibody levels to MsgC variants over time in HIV-infected men [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1211893247

    APA Style (7th edition)

  • Djawe, Kpandja. The changes of antibody levels to MsgC variants over time in HIV-infected men. 2008. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1211893247.

    MLA Style (8th edition)

  • Djawe, Kpandja. "The changes of antibody levels to MsgC variants over time in HIV-infected men." Master's thesis, University of Cincinnati, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1211893247

    Chicago Manual of Style (17th edition)

ucin1211893247
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© 2008, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.