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ucin1226071241.pdf (665.33 KB)
ETD Abstract Container
Abstract Header
Proposed Roles for Sox Transcription Factors and Growth Factor Receptors in NF1
Author Info
Sites, Emily
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1226071241
Abstract Details
Year and Degree
2008, MS, University of Cincinnati, Arts and Sciences : Biological Sciences.
Abstract
The molecular changes which occur downstream of the loss of
NF1
resulting in tumorigenesis are not well understood. Large-scale microarray analysis has given us clues as to which genes might be involved, but the nature of their interactions has yet to be elucidated. This work is aimed at dissecting the functional relationships between
EGFR
,
FGFR1
,
SOX9
and
SOX10
in
NF1
-null tumor models. We demonstrate that shRNA-mediated transcriptional knockdown of
SOX9
can downregulate
EGFR
and
FGFR1 in vitro
. Interfering with activity of either Egfr or Fgfr in an
Nf1-/-
mouse model has an effect on the survival/ proliferation of cells
in vitro
, and bFGF can rescue the effects of loss of Egfr signaling on these cells. Additionally, Egfr activity suppresses transcription of
Sox10
via p38Mapk. Taken together these data suggest a molecular mechanism for both the increased survival/proliferation and decreased differentiation that occur in the NF1 tumor environment.
Committee
Nancy Ratner, PhD (Advisor)
James Wells, PhD (Committee Member)
Katherine Yutzey, PhD (Committee Member)
Pages
44 p.
Subject Headings
Molecular Biology
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Citations
Sites, E. (2008).
Proposed Roles for Sox Transcription Factors and Growth Factor Receptors in NF1
[Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1226071241
APA Style (7th edition)
Sites, Emily.
Proposed Roles for Sox Transcription Factors and Growth Factor Receptors in NF1.
2008. University of Cincinnati, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1226071241.
MLA Style (8th edition)
Sites, Emily. "Proposed Roles for Sox Transcription Factors and Growth Factor Receptors in NF1." Master's thesis, University of Cincinnati, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1226071241
Chicago Manual of Style (17th edition)
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Document number:
ucin1226071241
Download Count:
343
Copyright Info
© 2008, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.