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Proposed Roles for Sox Transcription Factors and Growth Factor Receptors in NF1

Sites, Emily

Abstract Details

2008, MS, University of Cincinnati, Arts and Sciences : Biological Sciences.
The molecular changes which occur downstream of the loss of NF1 resulting in tumorigenesis are not well understood. Large-scale microarray analysis has given us clues as to which genes might be involved, but the nature of their interactions has yet to be elucidated. This work is aimed at dissecting the functional relationships between EGFR, FGFR1, SOX9 and SOX10 in NF1-null tumor models. We demonstrate that shRNA-mediated transcriptional knockdown of SOX9 can downregulate EGFR and FGFR1 in vitro. Interfering with activity of either Egfr or Fgfr in an Nf1-/- mouse model has an effect on the survival/ proliferation of cells in vitro, and bFGF can rescue the effects of loss of Egfr signaling on these cells. Additionally, Egfr activity suppresses transcription of Sox10 via p38Mapk. Taken together these data suggest a molecular mechanism for both the increased survival/proliferation and decreased differentiation that occur in the NF1 tumor environment.
Nancy Ratner, PhD (Advisor)
James Wells, PhD (Committee Member)
Katherine Yutzey, PhD (Committee Member)
44 p.

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Citations

  • Sites, E. (2008). Proposed Roles for Sox Transcription Factors and Growth Factor Receptors in NF1 [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1226071241

    APA Style (7th edition)

  • Sites, Emily. Proposed Roles for Sox Transcription Factors and Growth Factor Receptors in NF1. 2008. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1226071241.

    MLA Style (8th edition)

  • Sites, Emily. "Proposed Roles for Sox Transcription Factors and Growth Factor Receptors in NF1." Master's thesis, University of Cincinnati, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1226071241

    Chicago Manual of Style (17th edition)