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Database for the Study of Biological Pathways, with Wnt Signaling Pathway Use Case

Mailavaram, Sravanthi
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1227118211

Abstract Details

2009, MS, University of Cincinnati, Engineering : Computer Science.
The main focus of the work described in this thesis is to develop support for virtual experiments in systems biology in order to help biologists make choices about which wet lab experiments are likely to be the most informative, thereby saving both time and material resources. Understanding biological pathways is important for increasing our understanding of various diseases, such as cancer, and our ability to develop bio-engineered drugs to combat these diseases. A secondary goal is to support synthetic biology in general by providing tools which can be employed by biologists, engineers, and computational scientists. In particular, this work supports a previously developed algorithm, the box algorithm, for simulating a biological pathway and performing virtual experiments on it. We develop a bio-control database for algorithms such as the box algorithm, which focus on control of biological pathways. To demonstrate the working of our database, we develop a new use case for the box algorithm by studying the Wnt signaling pathway and showing how we can increase the concentration of APC*/Axin*/gsk-3, which is important in reducing the size of certain cancerous tumors.
Carla Purdy, PhD (Advisor)
George.B Purdy, PhD (Committee Member)
Han Chia-Yung, PhD (Committee Member)
108 p.
Computer Science
Pathways; Wnt Signaling Pathway; Wnt; Wnt Signaling; Database; Use Case; Axin

Recommended Citations

Citations

  • Mailavaram, S. (2009). Database for the Study of Biological Pathways, with Wnt Signaling Pathway Use Case [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1227118211

    APA Style (7th edition)

  • Mailavaram, Sravanthi. Database for the Study of Biological Pathways, with Wnt Signaling Pathway Use Case. 2009. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1227118211.

    MLA Style (8th edition)

  • Mailavaram, Sravanthi. "Database for the Study of Biological Pathways, with Wnt Signaling Pathway Use Case." Master's thesis, University of Cincinnati, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1227118211

    Chicago Manual of Style (17th edition)

ucin1227118211
869
© 2008, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.