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Dispensing and Diagnostics of Nano-liter Samples in Microreactors Using Electroosmotic Flow

Arumbuliyur Comandur, Kaushik
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1231963121

Abstract Details

2009, MS, University of Cincinnati, Engineering : Mechanical Engineering.
This study describes a microreactor design in which two samples are injectedsimultaneously, using electroosmotic flow and mixed in the microreactor. Both numerical and experimental investigations were carried to evaluate the pinching, switching and mixing of nanoliter sample volumes in the microreactor. The microreactor was fabricated on PDMS/glass hybrid and tested using fluorescein spectroscopy. The first step in this study was the pinch precise sample volumes are the center of microchannels. This was achieved by applying suitable voltages at the reservoirs. Different pinching conditions namely strong, medium and weak were obtained by controlling the voltages. The next step after pinching was to inject the samples to the microreactor. The timing of the sample injection was also controlled by changing the applied electric fields. In order to optimize the injection process effects of sample size and applied electric field on sample concentration were studied. It was found that the normalized final concentration of the sample increased from 0.03 to 0.11 as the sample length increased from 60 to 150 μm at constant electric field. Also, there was a decrease in the final concentration at the microreactor as the electric field strength increased. The concentration decreased from 0.14 at 100 V/cm to 0.04 at 1000 V/cm. The final study involved mixing the samples and modeling the reaction between the samples. The samples were allowed to mix in the microreactor for a period of 4.5 s. It is seen that normalized concentration of the product increases from 0.25 to 0.45 during that period.
Rupak K. Banerjee, Ph.D. (Committee Chair)
Ian Papautsky, Ph.D. (Committee Member)
Teik C. Lim, Ph.D. (Committee Member)
64 p.
Mechanical Engineering
Electroosmotic flow; Pinching; Switching; Microreactor; Reactions

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Citations

  • Arumbuliyur Comandur, K. (2009). Dispensing and Diagnostics of Nano-liter Samples in Microreactors Using Electroosmotic Flow [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1231963121

    APA Style (7th edition)

  • Arumbuliyur Comandur, Kaushik. Dispensing and Diagnostics of Nano-liter Samples in Microreactors Using Electroosmotic Flow. 2009. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1231963121.

    MLA Style (8th edition)

  • Arumbuliyur Comandur, Kaushik. "Dispensing and Diagnostics of Nano-liter Samples in Microreactors Using Electroosmotic Flow." Master's thesis, University of Cincinnati, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1231963121

    Chicago Manual of Style (17th edition)

ucin1231963121
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© 2009, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.