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Inertial microfluidics for particle separation and filtration

Bhagat, Ali Asgar Saleem
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1236123442

Abstract Details

2009, PhD, University of Cincinnati, Engineering : Electrical Engineering.
Filtration and separation of particles has numerous industrial and research applications in biology and medicine. In this work, inertial microfluidics is used to develop devices for continuous and passive separation and filtration of particles. Although particles are generally expected to follow laminar flow streamlines in the absence of external forces, inertial forces can cause particles to migrate across microchannels in an accurate and predictable manner. Thus, this work demonstrates how a simple spiral microfluidic channel can be used for high-throughput separation and filtration of particulate mixtures by exploiting these inertial forces and taking advantage of Dean forces present in curved channels. The developed technique was used to demonstrate a complete separation between 1.9 µm and 7.32 µm diameter polystyrene particles and filtration of red blood cells. The inertial forces can also be modulated by controlling fluidic shear in microchannels with rectangular, high aspect ratio cross-section in order to cause preferential particle migration. This approach was used successfully to demonstrate a complete filtration of 1.9 µm and 780 nm diameter particles in straight rectangular microchannels. The ability to continuously and passively focus particles based on size at high flow rates in microchannels is expected to have numerous applications in high-throughput bioparticle separation and filtration systems. The simple planar nature of the devices should permit easy integration with the existing lab-on-a-chip (LOC) systems.
Ian Papautsky, PhD (Committee Chair)
Chong Ahn, PhD (Committee Member)
Jason Heikenfeld, PhD (Committee Member)
Rupak Banerjee, PhD (Committee Member)
Dionysios Dionysiou, PhD (Committee Member)
105 p.
Electrical Engineering
inertial microfluidics; lab-on-a-chip; passive microfluidics; particle separation; particle filtration; continuous high-throughput separation

Recommended Citations

Citations

  • Bhagat, A. A. S. (2009). Inertial microfluidics for particle separation and filtration [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1236123442

    APA Style (7th edition)

  • Bhagat, Ali Asgar. Inertial microfluidics for particle separation and filtration. 2009. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1236123442.

    MLA Style (8th edition)

  • Bhagat, Ali Asgar. "Inertial microfluidics for particle separation and filtration." Doctoral dissertation, University of Cincinnati, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1236123442

    Chicago Manual of Style (17th edition)

ucin1236123442
1,385
© 2009, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.