Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


ucin1242133534.pdf (1.6 MB)

ETD Abstract Container

Abstract Header

Novel insights into the in vivo biology of Interleukin-10

Madan, Rajat
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1242133534

Abstract Details

2009, PhD, University of Cincinnati, Medicine : Molecular and Developmental Biology.
A proper inflammatory response is critical for the protection of host from microbial universe. However, inflammation can act as a double-edged sword – too little response can lead to pathogen-mediated damage whereas too much response can lead to immune-mediated damage. The immune responses thus need to be regulated in order to maintain homeostasis. While immunologists have traditionally focused on immune activation, a proper control and resolution of immune responses is equally important. Cytokines are short-lived protein mediators that play a crucial role in the regulation of immune responses. The focus of this dissertation has been the study of mechanistic regulation of two important immuno-regulatory cytokines: Interleukin-10 and Interleukin-12, in mouse models (in vivo) and in primary human cells (in vitro).Interleukin-10 is a pleotropic cytokine that is central to the restraining of inflammatory responses at all levels – local and systemic, innate and adaptive, and polarized along diverse axes of response. We have generated a novel transcriptional reporter mouse model (Vert-X) to study the critical cellular sources of this counter-regulatory cytokine in diverse models of infectious, autoimmune and allergic diseases. Transcriptional regulation of IL-12/23 p40 was investigated by using adenoviral constructs to transfect promoter/reporter constructs into primary human myeloid cells.
Christopher L. Karp (Committee Chair)
Jonathan D. Katz (Committee Member)
Mitchell B. Cohen (Committee Member)
Julio Aliberti (Committee Member)
Robert A. Colbert (Committee Member)
191 p.
Immunology; Molecular Biology
Cytokines; Interleukin-10; B cells

Recommended Citations

Citations

  • Madan, R. (2009). Novel insights into the in vivo biology of Interleukin-10 [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1242133534

    APA Style (7th edition)

  • Madan, Rajat. Novel insights into the in vivo biology of Interleukin-10. 2009. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1242133534.

    MLA Style (8th edition)

  • Madan, Rajat. "Novel insights into the in vivo biology of Interleukin-10." Doctoral dissertation, University of Cincinnati, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1242133534

    Chicago Manual of Style (17th edition)

ucin1242133534
595
© 2009, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.