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Characterizing the performance of a biological analogue to a digital inverter

Ghosh, Susmit Kumar
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1282327828

Abstract Details

2010, MS, University of Cincinnati, Engineering and Applied Science: Electrical Engineering.
The process of gene regulation in Phage Lambda, a virus infecting E Coli, is subject to attention for the development of a biological analogue to a digital inverter. We study in detail a model for a bioinverter based on the reactions given by Weiss. The Phage Lambda virus exhibits two phases, lysogeny and lysis. These two phases can be viewed as two stages of a digital inverter. We consider two models of the behavior of the system, i.e., deterministic and stochastic. The effects of various parameters of both the models are studied. We use statistical analysis to maximize the gain of the bioinverter. We determine that gain is attributed to a minimum number of reaction constants and to the initial concentration of protein species. This simplifies the task of the engineer who wishes to optimize the system for various applications.
Carla Purdy, C, PhD (Committee Chair)
George Purdy, PhD (Committee Member)
Wen Ben Jone, PhD (Committee Member)
86 p.
Computer Science
regression table; Cro; regression; StatTools; K7; Phage Lambda; behavior of the system

Recommended Citations

Citations

  • Ghosh, S. K. (2010). Characterizing the performance of a biological analogue to a digital inverter [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1282327828

    APA Style (7th edition)

  • Ghosh, Susmit. Characterizing the performance of a biological analogue to a digital inverter. 2010. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1282327828.

    MLA Style (8th edition)

  • Ghosh, Susmit. "Characterizing the performance of a biological analogue to a digital inverter." Master's thesis, University of Cincinnati, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1282327828

    Chicago Manual of Style (17th edition)

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© 2010, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.