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Preliminary Studies Investigating a Potential Role of an Intestinal Bacterium in the Development of Diet-Induced Obesity

Walters, Stephanie P.

Abstract Details

2010, MS, University of Cincinnati, Medicine: Immunology.
Obesity is a complex global health issue that has reached epidemic levels. It is estimated that 1.6 billion adults are overweight, with at least 400 million being obese. Obesity is linked to a variety of adverse sequelae, including insulin resistance, type 2 diabetes mellitus, dyslipidemia, coronary heart disease, hepatic steatosis, steatohepatitis and some types of cancer. Obesity is characterized by chronic low-grade inflammation. This includes activation of pro-inflammatory signaling pathways and the production of pro-inflammatory mediators that are pathophysiologically linked to these adverse sequelae. Many factors may contribute to the development of obesity, including the gut microbiome. Colonization of germ-free mice with the gut microbiome from obese mice results in a significant increase in total body fat compared to colonization with the gut microbiome from lean mice. In addition, obesity is associated with phylum-level shifts in the intestinal microbiome. The data reported here represent preliminary studies aimed at addressing the hypothesis that colonization with a specific commensal bacterial species is an important modifier of the response to high fat diet stress in inbred mice.
Christopher Karp, MD (Committee Chair)
Marsha Wills-Karp, PhD (Committee Member)
Kasper Hoebe, PhD (Committee Member)
Joseph Palumbo, MD (Committee Member)
59 p.

Recommended Citations

Citations

  • Walters, S. P. (2010). Preliminary Studies Investigating a Potential Role of an Intestinal Bacterium in the Development of Diet-Induced Obesity [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1282577742

    APA Style (7th edition)

  • Walters, Stephanie. Preliminary Studies Investigating a Potential Role of an Intestinal Bacterium in the Development of Diet-Induced Obesity. 2010. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1282577742.

    MLA Style (8th edition)

  • Walters, Stephanie. "Preliminary Studies Investigating a Potential Role of an Intestinal Bacterium in the Development of Diet-Induced Obesity." Master's thesis, University of Cincinnati, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1282577742

    Chicago Manual of Style (17th edition)