Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


ucin1298324553.pdf (10.28 MB)

ETD Abstract Container

Abstract Header

Notch pathway regulation of skeletal development and neural crest cell lineages in vivo

Mead, Timothy J.
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1298324553

Abstract Details

2011, PhD, University of Cincinnati, Medicine: Developmental Biology.
Congenital malformations are the most common cause of infant death in the United States. Skeletal and neural crest related structures, including cardiac outflow tract and craniofacial disorders, make up the majority of these malformations. Therefore, identifying molecular mechanisms that regulate skeletal and cardiac development is of great clinical importance. The Notch signaling pathway has been implicated in cell fate specification, migration, proliferation, and differentiation in a variety of cell types and organs and mis-expression of Notch signaling results in disease and associated malformations. Skeletogenesis encompasses several processes including somitogenesis, chondrogenesis, and osteogenesis that contribute to proper skeletal development. Notch signaling is necessary for proper somitogenesis and osteogenesis, but the role of Notch signaling in chondrogenesis in vivo was unknown. The studies detailed here demonstrate that Notch signaling is required for proper cartilage progenitor proliferation and hypertrophic chondrocyte differentiation in the axial and appendicular skeleton. During development, neural crest cells (NCCs) are formed in the dorsal neural tube and subsequently migrate, proliferate, and differentiate into a multitude of derivatives and structures including craniofacial and cardiac outflow tract derivatives. Notch signaling is also active in the neural crest and derivatives, but the mechanisms of Notch function at specific stages and developmental processes in NCC are unknown. Studies detailed in this dissertation demonstrate critical cell-autonomous roles for appropriate levels of Notch signaling during NCC migration, proliferation and differentiation with critical implications in craniofacial, cardiac, and neurogenic development and disease.
Katherine Yutzey, PhD (Committee Chair)
Robert Hinton, MS (Committee Member)
Steven Potter, PhD (Committee Member)
Nadean Brown, PhD (Committee Member)
Rhett Kovall, PhD (Committee Member)
237 p.
Developmental Biology
Notch; neural crest; chondrogenesis; skeletogenesis; outflow tract

Recommended Citations

Citations

  • Mead, T. J. (2011). Notch pathway regulation of skeletal development and neural crest cell lineages in vivo [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1298324553

    APA Style (7th edition)

  • Mead, Timothy. Notch pathway regulation of skeletal development and neural crest cell lineages in vivo. 2011. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1298324553.

    MLA Style (8th edition)

  • Mead, Timothy. "Notch pathway regulation of skeletal development and neural crest cell lineages in vivo." Doctoral dissertation, University of Cincinnati, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1298324553

    Chicago Manual of Style (17th edition)

ucin1298324553
528
© 2011, some rights reserved.Creative Commons License Notch pathway regulation of skeletal development and neural crest cell lineages in vivo by Timothy J. Mead is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by University of Cincinnati and OhioLINK.