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ucin1318862589.pdf (263.31 KB)
ETD Abstract Container
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Correlates of Resistin in Children with Chronic Kidney Disease: The CKiD Cohort
Author Info
Nehus, Edward J.
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1318862589
Abstract Details
Year and Degree
2011, MS, University of Cincinnati, Medicine: Clinical and Translational Research.
Abstract
Resistin, a 12.5 kDa protein, is produced by inflammatory cells and is elevated in patients with chronic kidney disease (CKD). While resistin was initially thought to mediate insulin resistance, more recent attention has focused on its role in inflammation and cardiovascular disease. This cross-sectional study analyzes the association of serum resistin with clinical and demographic parameters in the CKiD cohort, a large cohort of pediatric patients with stage II-IV CKD. In univariate analyses, serum resistin levels correlated negatively with glomerular filtration rate (GFR, p < 0.01). Increased serum resistin levels were associated with elevation of inflammatory cytokines, including interleukin-6 (IL-6, p < 0.01), interleukin-10 (p < 0.01), and tumor necrosis factor-a (p < 0.01). Resistin was not associated with insulin resistance (p = 0.13) as assessed by the homeostasis model assessment of insulin resistance (HOMA-IR), although it was positively correlated with serum triglycerides (p < 0.01) and negatively correlated with high-density lipoprotein cholesterol (p < 0.01). In multivariate analysis, only GFR, IL-6, pubertal status, and HOMA-IR were significantly associated with serum resistin. HOMA-IR, however, was negatively correlated with serum resistin. This was an unexpected finding that demonstrated an association of serum resistin levels with improved insulin sensitivity. IL-6 was strongly associated with resistin in multivariate analysis, suggesting that resistin is involved in the inflammatory milieu present in CKD and therefore may represent a novel risk factor for cardiovascular disease. Future prospective data will be needed to evaluate the predictive value of resistin in cardiovascular morbidity in children with CKD.
Committee
Paul Succop, PhD (Committee Chair)
Mark Mitsnefes, MD (Committee Member)
Erin Nicole Haynes, PHD (Committee Member)
Pages
31 p.
Subject Headings
Surgery
Keywords
chronic kidney disease
;
cardiovascular disease
;
inflammation
;
pediatrics
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Citations
Nehus, E. J. (2011).
Correlates of Resistin in Children with Chronic Kidney Disease: The CKiD Cohort
[Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1318862589
APA Style (7th edition)
Nehus, Edward.
Correlates of Resistin in Children with Chronic Kidney Disease: The CKiD Cohort.
2011. University of Cincinnati, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1318862589.
MLA Style (8th edition)
Nehus, Edward. "Correlates of Resistin in Children with Chronic Kidney Disease: The CKiD Cohort." Master's thesis, University of Cincinnati, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1318862589
Chicago Manual of Style (17th edition)
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Document number:
ucin1318862589
Download Count:
414
Copyright Info
© 2011, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.