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ucin1331300479.pdf (898.31 KB)
ETD Abstract Container
Abstract Header
Involvement of Complement in IgG2a-mediated Anaphylaxis
Author Info
Wang, Yunguan
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1331300479
Abstract Details
Year and Degree
2012, MS, University of Cincinnati, Medicine: Immunology.
Abstract
Anaphylaxis is an acute-onset and potentially fatal systemic allergic reaction affecting proximately 0.05 to 2% of the population worldwide and can be induced by a wide range of allergens from foods, medications and insect venoms. Although IgE is commonly involved in human anaphylaxis, other mediators, such as non-IgE antibodies and complement are also reported to be involved. Thus we sought to evaluate the role of complement in IgE-independent anaphylaxis. To approach this, we have studied an IgG2a-mediated passive systemic anaphylaxis model in mice with different backgrounds and gene deficiencies. We demonstrate that complement component 3 (C3) plays a major role in anaphylaxis in C57BL/6 and Balb/c mice sensitized with a low dose of IgG2aa mAb Hy1.2 but not in mice sensitized a higher dose of Hy1.2, and that C5 is not involved in IgG2a-mediated anaphylaxis.
Committee
Fred Finkelman, MD (Committee Chair)
David Hildeman, PhD (Committee Member)
Nives Zimmermann, PhD (Committee Member)
Pages
53 p.
Subject Headings
Immunology
Keywords
Anaphylaxis
;
IgG
;
Complement
;
C3a
;
C5a
;
platelet-activating factor
;
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Citations
Wang, Y. (2012).
Involvement of Complement in IgG2a-mediated Anaphylaxis
[Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1331300479
APA Style (7th edition)
Wang, Yunguan.
Involvement of Complement in IgG2a-mediated Anaphylaxis.
2012. University of Cincinnati, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1331300479.
MLA Style (8th edition)
Wang, Yunguan. "Involvement of Complement in IgG2a-mediated Anaphylaxis." Master's thesis, University of Cincinnati, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1331300479
Chicago Manual of Style (17th edition)
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Document number:
ucin1331300479
Download Count:
696
Copyright Info
© 2011, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.